Modulation of Ligand Selectivity Associated with Activation of the Transmembrane Region of the Human Follitropin Receptor

Recently, three naturally occurring mutations in the serpentine region of the FSH receptor (FSHr) (D567N and T449I/A) have been identified in three families with spontaneous ovarian hyperstimulation syndrome (OHSS). All mutant receptors displayed abnormally high sensitivity to human chorionic gonado...

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Veröffentlicht in:	Molecular endocrinology (Baltimore, Md.) Md.), 2004-08, Vol.18 (8), p.2061-2073
Hauptverfasser:	Montanelli, Lucia, Van Durme, Joost J. J, Smits, Guillaume, Bonomi, Marco, Rodien, Patrice, Devor, Eric J, Moffat-Wilson, Kristin, Pardo, Leonardo, Vassart, Gilbert, Costagliola, Sabine
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aspartic Acid - genetics Aspartic Acid - metabolism Cell Membrane - chemistry Cell Membrane - metabolism Cercopithecus aethiops COS Cells Cyclic AMP - metabolism Gene Expression Regulation Histidine - genetics Histidine - metabolism Humans Ligands Models, Molecular Mutation - genetics Protein Structure, Tertiary Receptors, FSH - chemistry Receptors, FSH - genetics Receptors, FSH - metabolism Structure-Activity Relationship Substrate Specificity Threonine - genetics Threonine - metabolism
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