Early Age at Menarche Associated with Cardiovascular Disease and Mortality
Context: The relationship between age at menarche and cardiovascular disease remains unclear. Two recent studies found an inverse association between age at menarche and all-cause mortality. Objective: The aim of this study was to examine the relationship between age at menarche and cardiovascular d...
Gespeichert in:
| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2009-12, Vol.94 (12), p.4953-4960 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 4960 |
|---|---|
| container_issue | 12 |
| container_start_page | 4953 |
| container_title | The journal of clinical endocrinology and metabolism |
| container_volume | 94 |
| creator | Lakshman, Rajalakshmi Forouhi, Nita G. Sharp, Stephen J. Luben, Robert Bingham, Sheila A. Khaw, Kay-Tee Wareham, Nicholas J. Ong, Ken K. |
| description | Context: The relationship between age at menarche and cardiovascular disease remains unclear. Two recent studies found an inverse association between age at menarche and all-cause mortality.
Objective: The aim of this study was to examine the relationship between age at menarche and cardiovascular disease risk factors, events, and mortality.
Design, Setting, and Participants: A population-based prospective study involving 15,807 women, aged 40–79 yr in 1993–1997 and followed up to March 2007 for cardiovascular disease events (median follow-up 10.6 yr) and February 2008 for mortality (median follow-up 12.0 yr) was used.
Main Outcome Measures: Odds ratios for cardiovascular disease risk factors and hazard ratios for incident cardiovascular disease and mortality were calculated.
Results: There were 3888 incident cardiovascular disease events (1323 coronary heart disease, 602 stroke, and 1963 other) and 1903 deaths (640 cardiovascular disease, 782 cancer, and 481 other) during follow-up. Compared with other women, those who had early menarche ( |
| doi_str_mv | 10.1210/jc.2009-1789 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1210_jc_2009_1789</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>19880785</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4474-31103ecd6e9a701cdaf032f4657e13f87ac4d1d7f4499fcef5ccccf9d54c732c3</originalsourceid><addsrcrecordid>eNptkDFv2zAQRokgReO43TIHWrJVKY-kTHE0nDRp4aBLC3QjruQxliNLBinH8L8vBRvJ0huOAPE-Hu8xdgX8FgTwr2t3Kzg3JejanLEJGFWVGow-ZxPOBZRGiz8X7DKlNeegVCU_sgswdc11XU3Yj3uM7aGYP1OBQ_FEHUa3omKeUu8aHMgX-2ZYFQuMvulfMbldi7G4axJhypHOF099HLBthsMn9iFgm-jz6Zyy39_ufy0ey-XPh--L-bJ0SmlVSgAuyfkZGdQcnMfApQhqVmkCGWqNTnnwOihlTHAUKpcrGF8pp6Vwcsq-HN91sU8pUrDb2GwwHixwOyqxa2dHJXZUkvHrI77d_d2Qf4dPDjJwcwLyetiGiJ1r0hsnhJAVyJFTR27ftwPF9NLu9hTtirAdVpbnUjNdl-NkyI2X443KMXmMUed7F5uOtpFSsut-F7vs6f-__gdhp4pB</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Early Age at Menarche Associated with Cardiovascular Disease and Mortality</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Alma/SFX Local Collection</source><creator>Lakshman, Rajalakshmi ; Forouhi, Nita G. ; Sharp, Stephen J. ; Luben, Robert ; Bingham, Sheila A. ; Khaw, Kay-Tee ; Wareham, Nicholas J. ; Ong, Ken K.</creator><creatorcontrib>Lakshman, Rajalakshmi ; Forouhi, Nita G. ; Sharp, Stephen J. ; Luben, Robert ; Bingham, Sheila A. ; Khaw, Kay-Tee ; Wareham, Nicholas J. ; Ong, Ken K.</creatorcontrib><description>Context: The relationship between age at menarche and cardiovascular disease remains unclear. Two recent studies found an inverse association between age at menarche and all-cause mortality.
Objective: The aim of this study was to examine the relationship between age at menarche and cardiovascular disease risk factors, events, and mortality.
Design, Setting, and Participants: A population-based prospective study involving 15,807 women, aged 40–79 yr in 1993–1997 and followed up to March 2007 for cardiovascular disease events (median follow-up 10.6 yr) and February 2008 for mortality (median follow-up 12.0 yr) was used.
Main Outcome Measures: Odds ratios for cardiovascular disease risk factors and hazard ratios for incident cardiovascular disease and mortality were calculated.
Results: There were 3888 incident cardiovascular disease events (1323 coronary heart disease, 602 stroke, and 1963 other) and 1903 deaths (640 cardiovascular disease, 782 cancer, and 481 other) during follow-up. Compared with other women, those who had early menarche (<12 yr) had higher risks of hypertension [1.13 (1.02–1.24)], incident cardiovascular disease [1.17 (1.07–1.27)], incident coronary heart disease [1.23 (1.06–1.43)], all-cause mortality [1.22 (1.07–1.39)], cardiovascular disease mortality [1.28 (1.02–1.62)], and cancer mortality [1.25 (1.03–1.51)], adjusted for age, physical activity, smoking, alcohol, educational level, occupational social class, oral contraceptive use, hormone replacement therapy, parity, body mass index, and waist circumference.
Conclusions: Early age at menarche (before age 12 yr) was associated with increased risk of cardiovascular disease events, cardiovascular disease mortality, and overall mortality in women, and this association appeared to be only partly mediated by increased adiposity.
Women with age at menarche before 12 years have higher risks of hypertension, cardiovascular disease, and total cardiovascular and cancer mortality than other women.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2009-1789</identifier><identifier>PMID: 19880785</identifier><identifier>CODEN: JCEMAZ</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Adiposity - physiology ; Adolescent ; Adult ; Aged ; Biological and medical sciences ; Body Mass Index ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - mortality ; Child ; Cohort Studies ; Diabetes Mellitus - epidemiology ; Endocrinopathies ; Feeding. Feeding behavior ; Female ; Follow-Up Studies ; Fundamental and applied biological sciences. Psychology ; Humans ; Life Style ; Medical sciences ; Menarche - physiology ; Middle Aged ; Neoplasms - epidemiology ; Odds Ratio ; Risk Factors ; United Kingdom - epidemiology ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vertebrates: endocrinology ; Waist Circumference</subject><ispartof>The journal of clinical endocrinology and metabolism, 2009-12, Vol.94 (12), p.4953-4960</ispartof><rights>Copyright © 2009 by The Endocrine Society</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4474-31103ecd6e9a701cdaf032f4657e13f87ac4d1d7f4499fcef5ccccf9d54c732c3</citedby><cites>FETCH-LOGICAL-c4474-31103ecd6e9a701cdaf032f4657e13f87ac4d1d7f4499fcef5ccccf9d54c732c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22235135$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19880785$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lakshman, Rajalakshmi</creatorcontrib><creatorcontrib>Forouhi, Nita G.</creatorcontrib><creatorcontrib>Sharp, Stephen J.</creatorcontrib><creatorcontrib>Luben, Robert</creatorcontrib><creatorcontrib>Bingham, Sheila A.</creatorcontrib><creatorcontrib>Khaw, Kay-Tee</creatorcontrib><creatorcontrib>Wareham, Nicholas J.</creatorcontrib><creatorcontrib>Ong, Ken K.</creatorcontrib><title>Early Age at Menarche Associated with Cardiovascular Disease and Mortality</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Context: The relationship between age at menarche and cardiovascular disease remains unclear. Two recent studies found an inverse association between age at menarche and all-cause mortality.
Objective: The aim of this study was to examine the relationship between age at menarche and cardiovascular disease risk factors, events, and mortality.
Design, Setting, and Participants: A population-based prospective study involving 15,807 women, aged 40–79 yr in 1993–1997 and followed up to March 2007 for cardiovascular disease events (median follow-up 10.6 yr) and February 2008 for mortality (median follow-up 12.0 yr) was used.
Main Outcome Measures: Odds ratios for cardiovascular disease risk factors and hazard ratios for incident cardiovascular disease and mortality were calculated.
Results: There were 3888 incident cardiovascular disease events (1323 coronary heart disease, 602 stroke, and 1963 other) and 1903 deaths (640 cardiovascular disease, 782 cancer, and 481 other) during follow-up. Compared with other women, those who had early menarche (<12 yr) had higher risks of hypertension [1.13 (1.02–1.24)], incident cardiovascular disease [1.17 (1.07–1.27)], incident coronary heart disease [1.23 (1.06–1.43)], all-cause mortality [1.22 (1.07–1.39)], cardiovascular disease mortality [1.28 (1.02–1.62)], and cancer mortality [1.25 (1.03–1.51)], adjusted for age, physical activity, smoking, alcohol, educational level, occupational social class, oral contraceptive use, hormone replacement therapy, parity, body mass index, and waist circumference.
Conclusions: Early age at menarche (before age 12 yr) was associated with increased risk of cardiovascular disease events, cardiovascular disease mortality, and overall mortality in women, and this association appeared to be only partly mediated by increased adiposity.
Women with age at menarche before 12 years have higher risks of hypertension, cardiovascular disease, and total cardiovascular and cancer mortality than other women.</description><subject>Adiposity - physiology</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cardiovascular Diseases - mortality</subject><subject>Child</subject><subject>Cohort Studies</subject><subject>Diabetes Mellitus - epidemiology</subject><subject>Endocrinopathies</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Life Style</subject><subject>Medical sciences</subject><subject>Menarche - physiology</subject><subject>Middle Aged</subject><subject>Neoplasms - epidemiology</subject><subject>Odds Ratio</subject><subject>Risk Factors</subject><subject>United Kingdom - epidemiology</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vertebrates: endocrinology</subject><subject>Waist Circumference</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkDFv2zAQRokgReO43TIHWrJVKY-kTHE0nDRp4aBLC3QjruQxliNLBinH8L8vBRvJ0huOAPE-Hu8xdgX8FgTwr2t3Kzg3JejanLEJGFWVGow-ZxPOBZRGiz8X7DKlNeegVCU_sgswdc11XU3Yj3uM7aGYP1OBQ_FEHUa3omKeUu8aHMgX-2ZYFQuMvulfMbldi7G4axJhypHOF099HLBthsMn9iFgm-jz6Zyy39_ufy0ey-XPh--L-bJ0SmlVSgAuyfkZGdQcnMfApQhqVmkCGWqNTnnwOihlTHAUKpcrGF8pp6Vwcsq-HN91sU8pUrDb2GwwHixwOyqxa2dHJXZUkvHrI77d_d2Qf4dPDjJwcwLyetiGiJ1r0hsnhJAVyJFTR27ftwPF9NLu9hTtirAdVpbnUjNdl-NkyI2X443KMXmMUed7F5uOtpFSsut-F7vs6f-__gdhp4pB</recordid><startdate>200912</startdate><enddate>200912</enddate><creator>Lakshman, Rajalakshmi</creator><creator>Forouhi, Nita G.</creator><creator>Sharp, Stephen J.</creator><creator>Luben, Robert</creator><creator>Bingham, Sheila A.</creator><creator>Khaw, Kay-Tee</creator><creator>Wareham, Nicholas J.</creator><creator>Ong, Ken K.</creator><general>Endocrine Society</general><general>Copyright by The Endocrine Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200912</creationdate><title>Early Age at Menarche Associated with Cardiovascular Disease and Mortality</title><author>Lakshman, Rajalakshmi ; Forouhi, Nita G. ; Sharp, Stephen J. ; Luben, Robert ; Bingham, Sheila A. ; Khaw, Kay-Tee ; Wareham, Nicholas J. ; Ong, Ken K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4474-31103ecd6e9a701cdaf032f4657e13f87ac4d1d7f4499fcef5ccccf9d54c732c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adiposity - physiology</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cardiovascular Diseases - mortality</topic><topic>Child</topic><topic>Cohort Studies</topic><topic>Diabetes Mellitus - epidemiology</topic><topic>Endocrinopathies</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Life Style</topic><topic>Medical sciences</topic><topic>Menarche - physiology</topic><topic>Middle Aged</topic><topic>Neoplasms - epidemiology</topic><topic>Odds Ratio</topic><topic>Risk Factors</topic><topic>United Kingdom - epidemiology</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vertebrates: endocrinology</topic><topic>Waist Circumference</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lakshman, Rajalakshmi</creatorcontrib><creatorcontrib>Forouhi, Nita G.</creatorcontrib><creatorcontrib>Sharp, Stephen J.</creatorcontrib><creatorcontrib>Luben, Robert</creatorcontrib><creatorcontrib>Bingham, Sheila A.</creatorcontrib><creatorcontrib>Khaw, Kay-Tee</creatorcontrib><creatorcontrib>Wareham, Nicholas J.</creatorcontrib><creatorcontrib>Ong, Ken K.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lakshman, Rajalakshmi</au><au>Forouhi, Nita G.</au><au>Sharp, Stephen J.</au><au>Luben, Robert</au><au>Bingham, Sheila A.</au><au>Khaw, Kay-Tee</au><au>Wareham, Nicholas J.</au><au>Ong, Ken K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early Age at Menarche Associated with Cardiovascular Disease and Mortality</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2009-12</date><risdate>2009</risdate><volume>94</volume><issue>12</issue><spage>4953</spage><epage>4960</epage><pages>4953-4960</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><coden>JCEMAZ</coden><abstract>Context: The relationship between age at menarche and cardiovascular disease remains unclear. Two recent studies found an inverse association between age at menarche and all-cause mortality.
Objective: The aim of this study was to examine the relationship between age at menarche and cardiovascular disease risk factors, events, and mortality.
Design, Setting, and Participants: A population-based prospective study involving 15,807 women, aged 40–79 yr in 1993–1997 and followed up to March 2007 for cardiovascular disease events (median follow-up 10.6 yr) and February 2008 for mortality (median follow-up 12.0 yr) was used.
Main Outcome Measures: Odds ratios for cardiovascular disease risk factors and hazard ratios for incident cardiovascular disease and mortality were calculated.
Results: There were 3888 incident cardiovascular disease events (1323 coronary heart disease, 602 stroke, and 1963 other) and 1903 deaths (640 cardiovascular disease, 782 cancer, and 481 other) during follow-up. Compared with other women, those who had early menarche (<12 yr) had higher risks of hypertension [1.13 (1.02–1.24)], incident cardiovascular disease [1.17 (1.07–1.27)], incident coronary heart disease [1.23 (1.06–1.43)], all-cause mortality [1.22 (1.07–1.39)], cardiovascular disease mortality [1.28 (1.02–1.62)], and cancer mortality [1.25 (1.03–1.51)], adjusted for age, physical activity, smoking, alcohol, educational level, occupational social class, oral contraceptive use, hormone replacement therapy, parity, body mass index, and waist circumference.
Conclusions: Early age at menarche (before age 12 yr) was associated with increased risk of cardiovascular disease events, cardiovascular disease mortality, and overall mortality in women, and this association appeared to be only partly mediated by increased adiposity.
Women with age at menarche before 12 years have higher risks of hypertension, cardiovascular disease, and total cardiovascular and cancer mortality than other women.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>19880785</pmid><doi>10.1210/jc.2009-1789</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-972X |
| ispartof | The journal of clinical endocrinology and metabolism, 2009-12, Vol.94 (12), p.4953-4960 |
| issn | 0021-972X 1945-7197 |
| language | eng |
| recordid | cdi_crossref_primary_10_1210_jc_2009_1789 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Adiposity - physiology Adolescent Adult Aged Biological and medical sciences Body Mass Index Cardiovascular Diseases - epidemiology Cardiovascular Diseases - mortality Child Cohort Studies Diabetes Mellitus - epidemiology Endocrinopathies Feeding. Feeding behavior Female Follow-Up Studies Fundamental and applied biological sciences. Psychology Humans Life Style Medical sciences Menarche - physiology Middle Aged Neoplasms - epidemiology Odds Ratio Risk Factors United Kingdom - epidemiology Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology Waist Circumference |
| title | Early Age at Menarche Associated with Cardiovascular Disease and Mortality |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-15T20%3A12%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Early%20Age%20at%20Menarche%20Associated%20with%20Cardiovascular%20Disease%20and%20Mortality&rft.jtitle=The%20journal%20of%20clinical%20endocrinology%20and%20metabolism&rft.au=Lakshman,%20Rajalakshmi&rft.date=2009-12&rft.volume=94&rft.issue=12&rft.spage=4953&rft.epage=4960&rft.pages=4953-4960&rft.issn=0021-972X&rft.eissn=1945-7197&rft.coden=JCEMAZ&rft_id=info:doi/10.1210/jc.2009-1789&rft_dat=%3Cpubmed_cross%3E19880785%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/19880785&rfr_iscdi=true |