Effects of the Phytoestrogen Genistein on the Circulating Soluble Receptor Activator of Nuclear Factor κB Ligand-Osteoprotegerin System in Early Postmenopausal Women
We investigated the serum levels of both receptor activator of nuclear factor κB ligand (RANKL) and its decoy receptor osteoprotegerin (OPG) in postmenopausal healthy women after a 1-yr therapy with genistein, (n = 30; 54 mg/d), hormone replacement therapy (n = 30; 1 mg/d 17β-estradiol combined with...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2004-01, Vol.89 (1), p.188-192 |
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| creator | Crisafulli, Alessandra Altavilla, Domenica Squadrito, Giovanni Romeo, Adolfo Adamo, Elena B. Marini, Rolando Inferrera, Maria A. Marini, Herbert Bitto, Alessandra D’anna, Rosario Corrado, Francesco Bartolone, Sebastiano Frisina, Nicola Squadrito, Francesco |
| description | We investigated the serum levels of both receptor activator of nuclear factor κB ligand (RANKL) and its decoy receptor osteoprotegerin (OPG) in postmenopausal healthy women after a 1-yr therapy with genistein, (n = 30; 54 mg/d), hormone replacement therapy (n = 30; 1 mg/d 17β-estradiol combined with norethisterone acetate) and placebo (n = 30). By comparison with placebo, the soluble RANKL (sRANKL)/OPG ratio was lower in the genistein group (−69 ± 7%; P < 0.01 vs. placebo 81 ± 24%) and in hormone replacement therapy-treated women (−11 ± 2%; P < 0.01 vs. placebo). A positive correlation (r = 0.63; P < 0.01) was found between 1-yr percentage change in sRANKL/OPG ratio and 1-yr change in urinary deoxypyridinoline, a bone resorption marker. A negative correlation was observed between 1-yr percentage change in sRANKL/OPG ratio and 1-yr change in femoral neck bone mineral density (r = −0.7; P < 0.01). Our findings suggest that the sRANKL-OPG system may mediate the beneficial effects of genistein on bone remodeling in postmenopausal women. |
| doi_str_mv | 10.1210/jc.2003-030891 |
| format | Article |
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By comparison with placebo, the soluble RANKL (sRANKL)/OPG ratio was lower in the genistein group (−69 ± 7%; P < 0.01 vs. placebo 81 ± 24%) and in hormone replacement therapy-treated women (−11 ± 2%; P < 0.01 vs. placebo). A positive correlation (r = 0.63; P < 0.01) was found between 1-yr percentage change in sRANKL/OPG ratio and 1-yr change in urinary deoxypyridinoline, a bone resorption marker. A negative correlation was observed between 1-yr percentage change in sRANKL/OPG ratio and 1-yr change in femoral neck bone mineral density (r = −0.7; P < 0.01). Our findings suggest that the sRANKL-OPG system may mediate the beneficial effects of genistein on bone remodeling in postmenopausal women.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2003-030891</identifier><identifier>CODEN: JCEMAZ</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Biological and medical sciences ; Bones, joints and connective tissue. Antiinflammatory agents ; Diseases of the osteoarticular system ; Medical sciences ; Osteoporosis. Osteomalacia. Paget disease ; Pharmacology. Drug treatments</subject><ispartof>The journal of clinical endocrinology and metabolism, 2004-01, Vol.89 (1), p.188-192</ispartof><rights>Copyright © 2004 by The Endocrine Society</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4006-18e8345d3b76ae421521eb5c41d6a78f97d5400c48572f515b2ac3f99880553</citedby><cites>FETCH-LOGICAL-c4006-18e8345d3b76ae421521eb5c41d6a78f97d5400c48572f515b2ac3f99880553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15456706$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Crisafulli, Alessandra</creatorcontrib><creatorcontrib>Altavilla, Domenica</creatorcontrib><creatorcontrib>Squadrito, Giovanni</creatorcontrib><creatorcontrib>Romeo, Adolfo</creatorcontrib><creatorcontrib>Adamo, Elena B.</creatorcontrib><creatorcontrib>Marini, Rolando</creatorcontrib><creatorcontrib>Inferrera, Maria A.</creatorcontrib><creatorcontrib>Marini, Herbert</creatorcontrib><creatorcontrib>Bitto, Alessandra</creatorcontrib><creatorcontrib>D’anna, Rosario</creatorcontrib><creatorcontrib>Corrado, Francesco</creatorcontrib><creatorcontrib>Bartolone, Sebastiano</creatorcontrib><creatorcontrib>Frisina, Nicola</creatorcontrib><creatorcontrib>Squadrito, Francesco</creatorcontrib><title>Effects of the Phytoestrogen Genistein on the Circulating Soluble Receptor Activator of Nuclear Factor κB Ligand-Osteoprotegerin System in Early Postmenopausal Women</title><title>The journal of clinical endocrinology and metabolism</title><description>We investigated the serum levels of both receptor activator of nuclear factor κB ligand (RANKL) and its decoy receptor osteoprotegerin (OPG) in postmenopausal healthy women after a 1-yr therapy with genistein, (n = 30; 54 mg/d), hormone replacement therapy (n = 30; 1 mg/d 17β-estradiol combined with norethisterone acetate) and placebo (n = 30). By comparison with placebo, the soluble RANKL (sRANKL)/OPG ratio was lower in the genistein group (−69 ± 7%; P < 0.01 vs. placebo 81 ± 24%) and in hormone replacement therapy-treated women (−11 ± 2%; P < 0.01 vs. placebo). A positive correlation (r = 0.63; P < 0.01) was found between 1-yr percentage change in sRANKL/OPG ratio and 1-yr change in urinary deoxypyridinoline, a bone resorption marker. A negative correlation was observed between 1-yr percentage change in sRANKL/OPG ratio and 1-yr change in femoral neck bone mineral density (r = −0.7; P < 0.01). Our findings suggest that the sRANKL-OPG system may mediate the beneficial effects of genistein on bone remodeling in postmenopausal women.</description><subject>Biological and medical sciences</subject><subject>Bones, joints and connective tissue. Antiinflammatory agents</subject><subject>Diseases of the osteoarticular system</subject><subject>Medical sciences</subject><subject>Osteoporosis. Osteomalacia. Paget disease</subject><subject>Pharmacology. 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Antiinflammatory agents</topic><topic>Diseases of the osteoarticular system</topic><topic>Medical sciences</topic><topic>Osteoporosis. Osteomalacia. Paget disease</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Crisafulli, Alessandra</creatorcontrib><creatorcontrib>Altavilla, Domenica</creatorcontrib><creatorcontrib>Squadrito, Giovanni</creatorcontrib><creatorcontrib>Romeo, Adolfo</creatorcontrib><creatorcontrib>Adamo, Elena B.</creatorcontrib><creatorcontrib>Marini, Rolando</creatorcontrib><creatorcontrib>Inferrera, Maria A.</creatorcontrib><creatorcontrib>Marini, Herbert</creatorcontrib><creatorcontrib>Bitto, Alessandra</creatorcontrib><creatorcontrib>D’anna, Rosario</creatorcontrib><creatorcontrib>Corrado, Francesco</creatorcontrib><creatorcontrib>Bartolone, Sebastiano</creatorcontrib><creatorcontrib>Frisina, Nicola</creatorcontrib><creatorcontrib>Squadrito, Francesco</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Crisafulli, Alessandra</au><au>Altavilla, Domenica</au><au>Squadrito, Giovanni</au><au>Romeo, Adolfo</au><au>Adamo, Elena B.</au><au>Marini, Rolando</au><au>Inferrera, Maria A.</au><au>Marini, Herbert</au><au>Bitto, Alessandra</au><au>D’anna, Rosario</au><au>Corrado, Francesco</au><au>Bartolone, Sebastiano</au><au>Frisina, Nicola</au><au>Squadrito, Francesco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of the Phytoestrogen Genistein on the Circulating Soluble Receptor Activator of Nuclear Factor κB Ligand-Osteoprotegerin System in Early Postmenopausal Women</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><date>2004-01</date><risdate>2004</risdate><volume>89</volume><issue>1</issue><spage>188</spage><epage>192</epage><pages>188-192</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><coden>JCEMAZ</coden><abstract>We investigated the serum levels of both receptor activator of nuclear factor κB ligand (RANKL) and its decoy receptor osteoprotegerin (OPG) in postmenopausal healthy women after a 1-yr therapy with genistein, (n = 30; 54 mg/d), hormone replacement therapy (n = 30; 1 mg/d 17β-estradiol combined with norethisterone acetate) and placebo (n = 30). By comparison with placebo, the soluble RANKL (sRANKL)/OPG ratio was lower in the genistein group (−69 ± 7%; P < 0.01 vs. placebo 81 ± 24%) and in hormone replacement therapy-treated women (−11 ± 2%; P < 0.01 vs. placebo). A positive correlation (r = 0.63; P < 0.01) was found between 1-yr percentage change in sRANKL/OPG ratio and 1-yr change in urinary deoxypyridinoline, a bone resorption marker. A negative correlation was observed between 1-yr percentage change in sRANKL/OPG ratio and 1-yr change in femoral neck bone mineral density (r = −0.7; P < 0.01). Our findings suggest that the sRANKL-OPG system may mediate the beneficial effects of genistein on bone remodeling in postmenopausal women.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><doi>10.1210/jc.2003-030891</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals |
| subjects | Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Diseases of the osteoarticular system Medical sciences Osteoporosis. Osteomalacia. Paget disease Pharmacology. Drug treatments |
| title | Effects of the Phytoestrogen Genistein on the Circulating Soluble Receptor Activator of Nuclear Factor κB Ligand-Osteoprotegerin System in Early Postmenopausal Women |
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