Effect of cocaine in early gestation on striatal dopamine and neurotrophic activity

Prenatal exposure to the dopamine (DA) agonist cocaine, even if limited to early gestation, is associated with impaired developmental outcome in the human infant. We investigated the possible role of neurotrophic factors in this process by evaluating 4- to 6-d-old New Zealand White rabbit pups (n =...

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Veröffentlicht in:	Pediatric research 1993-09, Vol.34 (3), p.389-392
Hauptverfasser:	WEESE-MAYER, D. E, SILVESTRI, J. M, DONGHUI LIN, BUHRFIEND, C. M, LO, E. S, CARVEY, P. M
Format:	Artikel
Sprache:	eng
Schlagworte:	3,4-Dihydroxyphenylacetic Acid - metabolism Abnormalities, Drug-Induced - embryology Abnormalities, Drug-Induced - etiology Abnormalities, Drug-Induced - metabolism Animals Apoptosis Biological and medical sciences Cells, Cultured Cerebellum - drug effects Cerebellum - embryology Cerebellum - metabolism Cocaine - pharmacology Cocaine - toxicity Corpus Striatum - abnormalities Corpus Striatum - drug effects Corpus Striatum - embryology Corpus Striatum - metabolism Corpus Striatum - pathology Dopamine - metabolism Drug addictions Female Medical sciences Pregnancy Rabbits Toxicology
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