Sorafenib Maintenance After Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia With FLT3 -Internal Tandem Duplication Mutation (SORMAIN)

Despite undergoing allogeneic hematopoietic stem cell transplantation (HCT), patients with acute myeloid leukemia (AML) with internal tandem duplication mutation in the like tyrosine kinase 3 gene ( ITD) have a poor prognosis, frequently relapse, and die as a result of AML. It is currently unknown w...

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Veröffentlicht in:	Journal of clinical oncology 2020-09, Vol.38 (26), p.2993-3002
Hauptverfasser:	Burchert, Andreas, Bug, Gesine, Fritz, Lea V, Finke, Jürgen, Stelljes, Matthias, Röllig, Christoph, Wollmer, Ellen, Wäsch, Ralph, Bornhäuser, Martin, Berg, Tobias, Lang, Fabian, Ehninger, Gerhard, Serve, Hubert, Zeiser, Robert, Wagner, Eva-Maria, Kröger, Nicolaus, Wolschke, Christine, Schleuning, Michael, Götze, Katharina S, Schmid, Christoph, Crysandt, Martina, Eßeling, Eva, Wolf, Dominik, Wang, Ying, Böhm, Alexandra, Thiede, Christian, Haferlach, Torsten, Michel, Christian, Bethge, Wolfgang, Wündisch, Thomas, Brandts, Christian, Harnisch, Susanne, Wittenberg, Michael, Hoeffkes, Heinz-Gert, Rospleszcz, Susanne, Burchardt, Alexander, Neubauer, Andreas, Brugger, Markus, Strauch, Konstantin, Schade-Brittinger, Carmen, Metzelder, Stephan K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Chemotherapy, Adjuvant Double-Blind Method Female fms-Like Tyrosine Kinase 3 - genetics Germany Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic Stem Cell Transplantation - mortality Humans Leukemia, Myeloid, Acute - enzymology Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - mortality Leukemia, Myeloid, Acute - therapy Maintenance Chemotherapy Male Middle Aged Mutation Neoplasm, Residual Protein Kinase Inhibitors - adverse effects Protein Kinase Inhibitors - therapeutic use Recurrence Sorafenib - adverse effects Sorafenib - therapeutic use Tandem Repeat Sequences Time Factors Transplantation, Homologous Treatment Outcome Young Adult
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