Dextrin-Microencapsulated Porphyrin: Luminescent Properties
Photophysical properties of porphyrins in aqueous solutions are strongly affected by aggregation. One possible solution to this problem is to encapsulate the porphyrin into polymeric spheres, to provide an environment where the photosensitizer can be administered in its monomeric form in such treatm...
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| Veröffentlicht in: | Annals of the New York Academy of Sciences 2008-05, Vol.1130 (1), p.91-96 |
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| container_title | Annals of the New York Academy of Sciences |
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| creator | Luz, Priscilla Paiva Neri, Cláudio Roberto Serra, Osvaldo Antonio |
| description | Photophysical properties of porphyrins in aqueous solutions are strongly affected by aggregation. One possible solution to this problem is to encapsulate the porphyrin into polymeric spheres, to provide an environment where the photosensitizer can be administered in its monomeric form in such treatments as photodynamic therapy. Here we report the microencapsulation of the meso‐tetrakis(4‐sulphonatophenyl) porphyrin (TPPS4) photosensitizer by the ultrasonic spray‐drying technique. The encapsulated TPPS4 was morphologically characterized by scanning electron microscopy, and its photophysical properties were studied and compared with those of a physical blend of dextrin and TPPS4. We successfully encapsulated TPPS4 into dextrin microspheres, and the encapsulated photosensitizer displays higher luminescence intensity than that of the prepared physical blends. |
| doi_str_mv | 10.1196/annals.1430.017 |
| format | Article |
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One possible solution to this problem is to encapsulate the porphyrin into polymeric spheres, to provide an environment where the photosensitizer can be administered in its monomeric form in such treatments as photodynamic therapy. Here we report the microencapsulation of the meso‐tetrakis(4‐sulphonatophenyl) porphyrin (TPPS4) photosensitizer by the ultrasonic spray‐drying technique. The encapsulated TPPS4 was morphologically characterized by scanning electron microscopy, and its photophysical properties were studied and compared with those of a physical blend of dextrin and TPPS4. We successfully encapsulated TPPS4 into dextrin microspheres, and the encapsulated photosensitizer displays higher luminescence intensity than that of the prepared physical blends.</description><identifier>ISSN: 0077-8923</identifier><identifier>EISSN: 1749-6632</identifier><identifier>DOI: 10.1196/annals.1430.017</identifier><identifier>PMID: 18596337</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>Chemistry, Physical - methods ; Desiccation ; Dextrins - chemistry ; Drug Compounding ; Light ; Luminescence ; Luminescent Proteins - chemistry ; microencapsulation ; Microscopy, Electron, Scanning ; Microspheres ; Models, Molecular ; Photochemistry - methods ; Photochemotherapy - methods ; photodynamic therapy ; Photosensitizing Agents - chemistry ; porphyrin ; Porphyrins - chemistry ; spray-drying</subject><ispartof>Annals of the New York Academy of Sciences, 2008-05, Vol.1130 (1), p.91-96</ispartof><rights>2008 New York Academy of Sciences</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4177-30f36bca2b683098d67814d28127af945174a942d956907a430652017990b4b03</citedby><cites>FETCH-LOGICAL-c4177-30f36bca2b683098d67814d28127af945174a942d956907a430652017990b4b03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1196%2Fannals.1430.017$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1196%2Fannals.1430.017$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18596337$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luz, Priscilla Paiva</creatorcontrib><creatorcontrib>Neri, Cláudio Roberto</creatorcontrib><creatorcontrib>Serra, Osvaldo Antonio</creatorcontrib><title>Dextrin-Microencapsulated Porphyrin: Luminescent Properties</title><title>Annals of the New York Academy of Sciences</title><addtitle>Ann N Y Acad Sci</addtitle><description>Photophysical properties of porphyrins in aqueous solutions are strongly affected by aggregation. One possible solution to this problem is to encapsulate the porphyrin into polymeric spheres, to provide an environment where the photosensitizer can be administered in its monomeric form in such treatments as photodynamic therapy. Here we report the microencapsulation of the meso‐tetrakis(4‐sulphonatophenyl) porphyrin (TPPS4) photosensitizer by the ultrasonic spray‐drying technique. The encapsulated TPPS4 was morphologically characterized by scanning electron microscopy, and its photophysical properties were studied and compared with those of a physical blend of dextrin and TPPS4. We successfully encapsulated TPPS4 into dextrin microspheres, and the encapsulated photosensitizer displays higher luminescence intensity than that of the prepared physical blends.</description><subject>Chemistry, Physical - methods</subject><subject>Desiccation</subject><subject>Dextrins - chemistry</subject><subject>Drug Compounding</subject><subject>Light</subject><subject>Luminescence</subject><subject>Luminescent Proteins - chemistry</subject><subject>microencapsulation</subject><subject>Microscopy, Electron, Scanning</subject><subject>Microspheres</subject><subject>Models, Molecular</subject><subject>Photochemistry - methods</subject><subject>Photochemotherapy - methods</subject><subject>photodynamic therapy</subject><subject>Photosensitizing Agents - chemistry</subject><subject>porphyrin</subject><subject>Porphyrins - chemistry</subject><subject>spray-drying</subject><issn>0077-8923</issn><issn>1749-6632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1PwkAYhDdGI4ievRn-QOHdj-6HnggqaBBJ1Kinzbbdxiq0zW6J8O9dUqJHT3t455mdGYTOMQwwVnxoytIs_QAzCgPA4gB1sWAq4pySQ9QFECKSitAOOvH-EwATycQx6mAZK06p6KKra7tpXFFGD0XqKlumpvbrpWls1l9Urv7Yhttlf7ZeFaX1qS2b_sJVtXVNYf0pOsrD7_Zs__bQy-3N83gazR4nd-PRLEoZDgEo5JQnqSEJlxSUzLiQmGVEYiJMrlgcIhvFSKZirkCY0IXHJLRRChKWAO2hYesbEnrvbK5rV6yM22oMejeDbmfQuxl0AANx0RL1OlnZ7E-_7x0EshV8F0u7_c9Pz99HTxhTaL2jFi18Yze_qHFfmgsqYv06n-i36f0chMKa0h91j3j8</recordid><startdate>200805</startdate><enddate>200805</enddate><creator>Luz, Priscilla Paiva</creator><creator>Neri, Cláudio Roberto</creator><creator>Serra, Osvaldo Antonio</creator><general>Blackwell Publishing Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200805</creationdate><title>Dextrin-Microencapsulated Porphyrin: Luminescent Properties</title><author>Luz, Priscilla Paiva ; Neri, Cláudio Roberto ; Serra, Osvaldo Antonio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4177-30f36bca2b683098d67814d28127af945174a942d956907a430652017990b4b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Chemistry, Physical - methods</topic><topic>Desiccation</topic><topic>Dextrins - chemistry</topic><topic>Drug Compounding</topic><topic>Light</topic><topic>Luminescence</topic><topic>Luminescent Proteins - chemistry</topic><topic>microencapsulation</topic><topic>Microscopy, Electron, Scanning</topic><topic>Microspheres</topic><topic>Models, Molecular</topic><topic>Photochemistry - methods</topic><topic>Photochemotherapy - methods</topic><topic>photodynamic therapy</topic><topic>Photosensitizing Agents - chemistry</topic><topic>porphyrin</topic><topic>Porphyrins - chemistry</topic><topic>spray-drying</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Luz, Priscilla Paiva</creatorcontrib><creatorcontrib>Neri, Cláudio Roberto</creatorcontrib><creatorcontrib>Serra, Osvaldo Antonio</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Annals of the New York Academy of Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luz, Priscilla Paiva</au><au>Neri, Cláudio Roberto</au><au>Serra, Osvaldo Antonio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dextrin-Microencapsulated Porphyrin: Luminescent Properties</atitle><jtitle>Annals of the New York Academy of Sciences</jtitle><addtitle>Ann N Y Acad Sci</addtitle><date>2008-05</date><risdate>2008</risdate><volume>1130</volume><issue>1</issue><spage>91</spage><epage>96</epage><pages>91-96</pages><issn>0077-8923</issn><eissn>1749-6632</eissn><abstract>Photophysical properties of porphyrins in aqueous solutions are strongly affected by aggregation. One possible solution to this problem is to encapsulate the porphyrin into polymeric spheres, to provide an environment where the photosensitizer can be administered in its monomeric form in such treatments as photodynamic therapy. Here we report the microencapsulation of the meso‐tetrakis(4‐sulphonatophenyl) porphyrin (TPPS4) photosensitizer by the ultrasonic spray‐drying technique. The encapsulated TPPS4 was morphologically characterized by scanning electron microscopy, and its photophysical properties were studied and compared with those of a physical blend of dextrin and TPPS4. We successfully encapsulated TPPS4 into dextrin microspheres, and the encapsulated photosensitizer displays higher luminescence intensity than that of the prepared physical blends.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>18596337</pmid><doi>10.1196/annals.1430.017</doi><tpages>6</tpages></addata></record> |
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| ispartof | Annals of the New York Academy of Sciences, 2008-05, Vol.1130 (1), p.91-96 |
| issn | 0077-8923 1749-6632 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Chemistry, Physical - methods Desiccation Dextrins - chemistry Drug Compounding Light Luminescence Luminescent Proteins - chemistry microencapsulation Microscopy, Electron, Scanning Microspheres Models, Molecular Photochemistry - methods Photochemotherapy - methods photodynamic therapy Photosensitizing Agents - chemistry porphyrin Porphyrins - chemistry spray-drying |
| title | Dextrin-Microencapsulated Porphyrin: Luminescent Properties |
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