Role of Iron in Inducing Oxidative Stress in Thalassemia: Can It Be Prevented by Inhibition of Absorption and by Antioxidants?

: The pathophysiology of thalassemia is, to a certain extent, associated with the generation of labile iron in the pathological red blood cell (RBC). The appearance of such forms of iron at the inner and outer cell surfaces exposes the cell to conditions whereby the labile metal promotes the formati...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Annals of the New York Academy of Sciences 2005-11, Vol.1054 (1), p.118-123
Hauptverfasser:	RACHMILEWITZ, ELIEZER A., WEIZER-STERN, ORLY, ADAMSKY, KONSTANTIN, AMARIGLIO, NINETTE, RECHAVI, GIDEON, BREDA, LAURA, RIVELLA, STEFANO, CABANTCHIK, Z IOAV
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - administration & dosage Acetylcysteine - therapeutic use Animals Antimicrobial Cationic Peptides - biosynthesis Antimicrobial Cationic Peptides - genetics antioxidant Antioxidants - administration & dosage Antioxidants - pharmacology Antioxidants - therapeutic use Bone Marrow - metabolism Carcinoma, Hepatocellular - pathology Cell Line, Tumor Disease Models, Animal Drug Therapy, Combination Erythrocytes - chemistry Gene Expression Regulation Genetic Therapy hepcidin Hepcidins Humans Intestinal Absorption - physiology Iron - adverse effects Iron - blood Iron - chemistry Iron - pharmacokinetics Iron - physiology Iron Chelating Agents - administration & dosage Iron Chelating Agents - therapeutic use iron overload Iron, Dietary - pharmacokinetics Liver Neoplasms - pathology Mice Oxidants - chemistry Oxidants - pharmacokinetics Oxidative Stress thalassemia Thalassemia - drug therapy Thalassemia - metabolism Thalassemia - physiopathology Vitamin E - administration & dosage Vitamin E - therapeutic use
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!