Adolescent Ethanol Sensitivity: Hypothermia and Acute Tolerance
: A two‐injection paradigm was used to assess acute (within‐session) tolerance to ethanol in telemetry‐implanted adolescent and adult rats. Male rats were intragastrically pretreated with either 1.0 g/kg of ethanol or water and then challenged with 2.0 g/kg of ethanol or water when blood alcohol lev...
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| Veröffentlicht in: | Annals of the New York Academy of Sciences 2004-06, Vol.1021 (1), p.445-447 |
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| container_title | Annals of the New York Academy of Sciences |
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| creator | RISTUCCIA, R C SPEAR, L P |
| description | : A two‐injection paradigm was used to assess acute (within‐session) tolerance to ethanol in telemetry‐implanted adolescent and adult rats. Male rats were intragastrically pretreated with either 1.0 g/kg of ethanol or water and then challenged with 2.0 g/kg of ethanol or water when blood alcohol levels (BALs) of ethanol‐pretreated animals were anticipated to approach zero. Adults showed more rapid and sustained ethanol‐induced hypothermia than adolescents. Acute tolerance to ethanol‐induced hypothermia did not emerge clearly with the two‐injection paradigm; ethanol‐pretreated animals of both ages generally did not differ from those pretreated with water in their hypothermic response to ethanol despite higher BALs after the second intubation. Housing condition (paired or isolated) had little influence on ethanol‐induced hypothermia. The adolescent attenuation of ethanol‐induced hypothermia in this experiment was not associated with greater expression of within‐session (acute) tolerance. |
| doi_str_mv | 10.1196/annals.1308.061 |
| format | Article |
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Male rats were intragastrically pretreated with either 1.0 g/kg of ethanol or water and then challenged with 2.0 g/kg of ethanol or water when blood alcohol levels (BALs) of ethanol‐pretreated animals were anticipated to approach zero. Adults showed more rapid and sustained ethanol‐induced hypothermia than adolescents. Acute tolerance to ethanol‐induced hypothermia did not emerge clearly with the two‐injection paradigm; ethanol‐pretreated animals of both ages generally did not differ from those pretreated with water in their hypothermic response to ethanol despite higher BALs after the second intubation. Housing condition (paired or isolated) had little influence on ethanol‐induced hypothermia. The adolescent attenuation of ethanol‐induced hypothermia in this experiment was not associated with greater expression of within‐session (acute) tolerance.</description><identifier>ISSN: 0077-8923</identifier><identifier>EISSN: 1749-6632</identifier><identifier>DOI: 10.1196/annals.1308.061</identifier><identifier>PMID: 15251926</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>activity ; acute tolerance ; adolescence ; Age Factors ; Animals ; Animals, Newborn ; Behavior, Animal ; body temperature ; Body Temperature - drug effects ; Central Nervous System Depressants - adverse effects ; Central Nervous System Depressants - blood ; Central Nervous System Depressants - pharmacology ; Drug Administration Routes ; Drug Tolerance ; Ethanol - adverse effects ; Ethanol - blood ; Ethanol - pharmacology ; ethanol hypothermia ; ethanol sensitivity ; Hypothermia - chemically induced ; Hypothermia, Induced - methods ; Male ; Rats ; Rats, Sprague-Dawley ; Sensitivity and Specificity ; Social Isolation ; Sprague-Dawley rat ; Telemetry</subject><ispartof>Annals of the New York Academy of Sciences, 2004-06, Vol.1021 (1), p.445-447</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4175-da7d72274ea0c604e4555be571fa737954f02134da870e365e470bce14b8750b3</citedby><cites>FETCH-LOGICAL-c4175-da7d72274ea0c604e4555be571fa737954f02134da870e365e470bce14b8750b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1196%2Fannals.1308.061$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1196%2Fannals.1308.061$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15251926$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>RISTUCCIA, R C</creatorcontrib><creatorcontrib>SPEAR, L P</creatorcontrib><title>Adolescent Ethanol Sensitivity: Hypothermia and Acute Tolerance</title><title>Annals of the New York Academy of Sciences</title><addtitle>Ann N Y Acad Sci</addtitle><description>: A two‐injection paradigm was used to assess acute (within‐session) tolerance to ethanol in telemetry‐implanted adolescent and adult rats. Male rats were intragastrically pretreated with either 1.0 g/kg of ethanol or water and then challenged with 2.0 g/kg of ethanol or water when blood alcohol levels (BALs) of ethanol‐pretreated animals were anticipated to approach zero. Adults showed more rapid and sustained ethanol‐induced hypothermia than adolescents. Acute tolerance to ethanol‐induced hypothermia did not emerge clearly with the two‐injection paradigm; ethanol‐pretreated animals of both ages generally did not differ from those pretreated with water in their hypothermic response to ethanol despite higher BALs after the second intubation. Housing condition (paired or isolated) had little influence on ethanol‐induced hypothermia. The adolescent attenuation of ethanol‐induced hypothermia in this experiment was not associated with greater expression of within‐session (acute) tolerance.</description><subject>activity</subject><subject>acute tolerance</subject><subject>adolescence</subject><subject>Age Factors</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Behavior, Animal</subject><subject>body temperature</subject><subject>Body Temperature - drug effects</subject><subject>Central Nervous System Depressants - adverse effects</subject><subject>Central Nervous System Depressants - blood</subject><subject>Central Nervous System Depressants - pharmacology</subject><subject>Drug Administration Routes</subject><subject>Drug Tolerance</subject><subject>Ethanol - adverse effects</subject><subject>Ethanol - blood</subject><subject>Ethanol - pharmacology</subject><subject>ethanol hypothermia</subject><subject>ethanol sensitivity</subject><subject>Hypothermia - chemically induced</subject><subject>Hypothermia, Induced - methods</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Sensitivity and Specificity</subject><subject>Social Isolation</subject><subject>Sprague-Dawley rat</subject><subject>Telemetry</subject><issn>0077-8923</issn><issn>1749-6632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1Lw0AURQdRbK2u3Un-QNr5nsSNBK2tUKrSiLgaJskLjaaTkknV_HtTUnTp6m3uubx7ELokeExIKCfGWlO6MWE4GGNJjtCQKB76UjJ6jIYYK-UHIWUDdObcO8aEBlydogERVJCQyiG6ibKqBJeCbbxpsza2Kr0VWFc0xWfRtNfevN1WzRrqTWE8YzMvSncNeHEH1camcI5O8u4DuDjcEXq5n8a3c3_xOHu4jRZ-yokSfmZUpihVHAxOJebAhRAJCEVyo5gKBc8xJYxnJlAYmBTAFU5SIDwJlMAJG6FJ35vWlXM15HpbFxtTt5pgvVehexV6r0J3Kjriqie2u2QD2V_-sL0L8D7wVZTQ_tenl2_RinPRYX6PFa6B71_M1B9adlOEfl3OdPx0Fy-fGdMz9gPuJHpl</recordid><startdate>200406</startdate><enddate>200406</enddate><creator>RISTUCCIA, R C</creator><creator>SPEAR, L P</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200406</creationdate><title>Adolescent Ethanol Sensitivity: Hypothermia and Acute Tolerance</title><author>RISTUCCIA, R C ; SPEAR, L P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4175-da7d72274ea0c604e4555be571fa737954f02134da870e365e470bce14b8750b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>activity</topic><topic>acute tolerance</topic><topic>adolescence</topic><topic>Age Factors</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Behavior, Animal</topic><topic>body temperature</topic><topic>Body Temperature - drug effects</topic><topic>Central Nervous System Depressants - adverse effects</topic><topic>Central Nervous System Depressants - blood</topic><topic>Central Nervous System Depressants - pharmacology</topic><topic>Drug Administration Routes</topic><topic>Drug Tolerance</topic><topic>Ethanol - adverse effects</topic><topic>Ethanol - blood</topic><topic>Ethanol - pharmacology</topic><topic>ethanol hypothermia</topic><topic>ethanol sensitivity</topic><topic>Hypothermia - chemically induced</topic><topic>Hypothermia, Induced - methods</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Sensitivity and Specificity</topic><topic>Social Isolation</topic><topic>Sprague-Dawley rat</topic><topic>Telemetry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>RISTUCCIA, R C</creatorcontrib><creatorcontrib>SPEAR, L P</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Annals of the New York Academy of Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>RISTUCCIA, R C</au><au>SPEAR, L P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adolescent Ethanol Sensitivity: Hypothermia and Acute Tolerance</atitle><jtitle>Annals of the New York Academy of Sciences</jtitle><addtitle>Ann N Y Acad Sci</addtitle><date>2004-06</date><risdate>2004</risdate><volume>1021</volume><issue>1</issue><spage>445</spage><epage>447</epage><pages>445-447</pages><issn>0077-8923</issn><eissn>1749-6632</eissn><abstract>: A two‐injection paradigm was used to assess acute (within‐session) tolerance to ethanol in telemetry‐implanted adolescent and adult rats. Male rats were intragastrically pretreated with either 1.0 g/kg of ethanol or water and then challenged with 2.0 g/kg of ethanol or water when blood alcohol levels (BALs) of ethanol‐pretreated animals were anticipated to approach zero. Adults showed more rapid and sustained ethanol‐induced hypothermia than adolescents. Acute tolerance to ethanol‐induced hypothermia did not emerge clearly with the two‐injection paradigm; ethanol‐pretreated animals of both ages generally did not differ from those pretreated with water in their hypothermic response to ethanol despite higher BALs after the second intubation. Housing condition (paired or isolated) had little influence on ethanol‐induced hypothermia. The adolescent attenuation of ethanol‐induced hypothermia in this experiment was not associated with greater expression of within‐session (acute) tolerance.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>15251926</pmid><doi>10.1196/annals.1308.061</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Annals of the New York Academy of Sciences, 2004-06, Vol.1021 (1), p.445-447 |
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| language | eng |
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| subjects | activity acute tolerance adolescence Age Factors Animals Animals, Newborn Behavior, Animal body temperature Body Temperature - drug effects Central Nervous System Depressants - adverse effects Central Nervous System Depressants - blood Central Nervous System Depressants - pharmacology Drug Administration Routes Drug Tolerance Ethanol - adverse effects Ethanol - blood Ethanol - pharmacology ethanol hypothermia ethanol sensitivity Hypothermia - chemically induced Hypothermia, Induced - methods Male Rats Rats, Sprague-Dawley Sensitivity and Specificity Social Isolation Sprague-Dawley rat Telemetry |
| title | Adolescent Ethanol Sensitivity: Hypothermia and Acute Tolerance |
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