Are the protective effects of 17β-estradiol on splenic macrophages and splenocytes after trauma-hemorrhage mediated via estrogen-receptor (ER)-α or ER-β?

The depression in cell‐mediated immune function following trauma‐hemorrhage is shown to be restored by 17β‐estradiol (E2) administration. However, it remains unknown which of the two estrogen‐receptors, (ER)‐α or ER‐β, plays the predominant role in mediating the beneficial effects of E2. Female B57B...

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Veröffentlicht in:	Journal of leukocyte biology 2006-06, Vol.79 (6), p.1173-1180
Hauptverfasser:	Hildebrand, Frank, Hubbard, William J., Choudhry, Mashkoor A., Thobe, Bjoern M., Pape, Hans‐Christoph, Chaudry, Irshad H.
Format:	Artikel
Sprache:	eng
Schlagworte:	immune response injury knockout propyl pyrazole triol sex hormones shock
Online-Zugang:	Volltext
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