Sodium cromoglycate and doxantrazole are oxygen radical scavengers

The effects of two mast cell stabilisers, sodium cromoglycate (SCG) and doxantrazole, on the formation of reactive oxygen species (ROS) were studied. Guinea-pig alveolar macrophages (AMs) generated lucigenin-dependent chemiluminescence (LDCL). This was increased when the cells were stimulated by pho...

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Veröffentlicht in:	The European respiratory journal 2002-10, Vol.20 (4), p.867-872
Hauptverfasser:	Sadeghi-Hashjin, G, Nijkamp, F.P, Henricks, P.A.J, Folkerts, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Bronchoalveolar Lavage Fluid - cytology Cells, Cultured Cromolyn Sodium - pharmacology Dose-Response Relationship, Drug Drug Interactions Female Guinea Pigs Luminescent Measurements Macrophages, Alveolar - drug effects Macrophages, Alveolar - physiology Male Medical sciences Models, Animal Pharmacology. Drug treatments Probability Reactive Oxygen Species - metabolism Reference Values Respiratory system Sensitivity and Specificity Tetradecanoylphorbol Acetate - pharmacology Thioxanthenes - pharmacology Xanthones Zymosan - pharmacology
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