Inhibiting autophagy targets human leukemic stem cells and hypoxic AML blasts by disrupting mitochondrial homeostasis

Leukemia stem cells (LSCs) and therapy-resistant acute myeloid leukemia (AML) blasts contribute to the reinitiation of leukemia after remission, necessitating therapeutic interventions that target these populations. Autophagy is a prosurvival process that allows for cells to adapt to a variety of st...

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Veröffentlicht in:	Blood advances 2021-04, Vol.5 (8), p.2087-2100
Hauptverfasser:	Dykstra, Kaitlyn M., Fay, Hannah R.S., Massey, Ashish C., Yang, Neng, Johnson, Matthew, Portwood, Scott, Guzman, Monica L., Wang, Eunice S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autophagy Hematology Homeostasis Humans Hypoxia Leukemia, Myeloid, Acute - drug therapy Life Sciences & Biomedicine Mice Mitochondria Myeloid Neoplasia Science & Technology Stem Cells Tumor Microenvironment
Online-Zugang:	Volltext
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