Computational Discovery and Validation of NAD+ Biosynthesis As Unique Vulnerability in B-Lymphoid Malignancies

Background and Significance: Glucocorticoids have been a mainstay in virtually all therapy regimens for B-lymphoid malignancies since the 1950s. Glucocorticoids selectively kill B-cell leukemia and lymphoma cells but have very limited effects on myeloid and epithelial cells. Likewise, inhibitors of...

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Veröffentlicht in:	Blood 2023-11, Vol.142 (Supplement 1), p.418-418
Hauptverfasser:	Li, Qin, Robinson, Mark E, Leveille, Etienne, Zhang, Chang, Sun, Ruifeng, Cheng, Zhangliang, Kume, Kohei, Cosgun, Kadriye Nehir, Kothari, Shalin, Khanduja, Dhruv, Nakada, Daisuke, Müschen, Markus
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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