Forward Genetic Screen Implicates Drivers of Leukemic Progression in a Novel Model of Trp53 R270H myelodysplastic Syndrome

Myelodysplastic syndrome (MDS) is characterized by bone marrow failure and a highly variable clinical course. The most catastrophic complication of MDS is transformation to secondary acute myeloid leukemia (sAML). Notably, mutations in TP53 confer the single highest risk of transformation to sAML an...

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Veröffentlicht in:	Blood 2023-11, Vol.142 (Supplement 1), p.315-315
Hauptverfasser:	Chang, Daniel, Noble-Orcutt, Klara E, Hudson, Wendy, Iyer, Aishwarya, Pomeroy, Emily, Eckfeldt, Craig E., Sarver, Aaron, Temiz, Nuri Alpay, Linden, Michael, Myers, Chad L, Largaespada, David A., Sachs, Zohar
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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