Transcranial Doppler Screening of Children with Sickle Cell Disease for a Large, Multinational Interventional Study: Experience from the Phase 3 HOPE-Kids 2 Trial Investigating the Effect of Voxelotor Treatment on Transcranial Doppler Flow Velocity
Introduction: Transcranial Doppler (TCD) ultrasound is an effective screening tool for identifying children with sickle cell disease (SCD) who are at high risk of stroke. Implementing TCD screening, along with appropriate therapies, for the purpose of primary stroke prevention in resource-constraine...
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| Veröffentlicht in: | Blood 2023-11, Vol.142 (Supplement 1), p.3871-3871 |
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| creator | Bello-Manga, Halima Nduba, Videlis Abdullahi, Shehu Umar Githanga, Jessie Ogutu, Bernhards El-Beshlawy, Amal M. Hassab, Hoda MA Badr, Mohamed Tantawy, Azza Brown, Biobele J Paintsil, Vivian Akinsete, Adeseye Michael Segbefia, Catherine I. Okpala, Iheanyi Wali, Yasser Essa, Mohammed Farthing, Jason Doss, Jennifer Dixon, Sandy Brown, Clark Kirkham, Fenella |
| description | Introduction: Transcranial Doppler (TCD) ultrasound is an effective screening tool for identifying children with sickle cell disease (SCD) who are at high risk of stroke. Implementing TCD screening, along with appropriate therapies, for the purpose of primary stroke prevention in resource-constrained settings remains challenging. HOPE-KIDS 2 (NCT04218084) is an ongoing, phase 3, multicenter, double-blind, placebo-controlled trial of voxelotor in children with SCD and elevated arterial cerebral blood flow (measured by time-averaged maximum of the mean velocity [TAMMV]). Our aim is to describe the findings from successful implementation of a standardized TCD screening protocol that was conducted in a multinational setting.
Methods: The purpose of HOPE-KIDS 2 is to evaluate the effect of voxelotor treatment on reducing the risk of stroke in participants aged 2 to |
| doi_str_mv | 10.1182/blood-2023-188677 |
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Methods: The purpose of HOPE-KIDS 2 is to evaluate the effect of voxelotor treatment on reducing the risk of stroke in participants aged 2 to <15 years with SCD who have conditional TAMMV (170 to <200 cm/s) at baseline. Children aged 2 to <15 years with SCD (HbSS/HbSβ 0) were screened after local sonographers were trained and certified on standardized TCD examination protocol, using the same model of Multi-Dop T digital machine (Compumedics DWL, Germany). TCD assessments were sent for central quality review and interpretation by 2 independent reviewers. STOP criteria were used to classify stroke risk: normal, <170 cm/s; conditional, 170 to <200 cm/s; or abnormal, ≥200 cm/s. Patient baseline characteristics, including clinical measurements of markers of anemia and hemolysis, were measured during study screening. The reasons for patient screen failure were summarized.
Results: Between Nov 2020 and Feb 2023, 708 participants consented at 29 sites in Nigeria (n=250; 5 sites), Kenya (n=241; 4 sites), Egypt (n=145; 4 sites), Ghana (n=28; 2 sites), the US (n=17; 8 sites), Italy (n=9; 3 sites), Oman (n=9; 1 site), Saudi Arabia (n=8; 1 site), and the UK (n=1; 1 site). Of these patients, 92.1% (652/708) completed TCD screening examinations (mean [SD] age 7.6 [3.24] years; range 2.0-14.0 years; 50.8% male; 23.0% receiving hydroxyurea). Of the patients who completed TCD screening, the mean (SD) TAMMV was 163.0 (31.26) cm/s, and 47.1% (307/652) had conditional TCD at baseline (29.0% low conditional, 18.1% high conditional). The main reason for screen failure was index TAMMV outside of conditional range (abnormal, n=39 [6.0%]; normal, n=306 [46.9%]). Elevated TAMMV on screening TCD was more common in younger children (2 to ≤8 years vs >8 to <15 years); patients aged 2-8 years comprised 66.8% and 82.1% of the conditional and abnormal TCD categories, respectively. There were 39 assessments that required adjudication, but only 9 were deemed unreadable. Of all patients screened, 36.2% (236/652) fulfilled eligibility criteria for randomization; the characteristics at screening of these patients are summarized (Table). The mean (SD) Hb level and TAMMV at screening for randomly assigned patients was 7.7 (1.06) g/dL and 182.7 (7.53) cm/s, respectively.
Conclusions: Clinical sites for the HOPE-KIDS 2 study successfully implemented a standardized, local TCD screening protocol supported by central quality review. For a large interventional trial aimed at reducing the risk of stroke in children with SCD, African and Middle Eastern sites presented relatively few limitations with respect to participant screening.
Bello-Manga:Global Blood Therapeutics/Pfizer: Consultancy; Forma Therapeutics/Novo Nordisk: Other: Clinical trial activity; National Institutes of Health Fogarty International Center (K43TW011583): Research Funding. El-Beshlawy:Global Blood Therapeutics: Research Funding. Hassab:Global Blood Therapeutics: Research Funding. Wali:Global Blood Therapeutics: Honoraria, Research Funding. Farthing:Pfizer Inc: Current Employment, Current holder of stock options in a privately-held company; Global Blood Therapeutics: Ended employment in the past 24 months. Doss:Pfizer Inc: Current Employment, Current holder of stock options in a privately-held company; Global Blood Therapeutics: Ended employment in the past 24 months. Dixon:Pfizer Inc: Current Employment, Current holder of stock options in a privately-held company; Global Blood Therapeutics: Ended employment in the past 24 months. Brown:Pfizer Inc: Current Employment, Current holder of stock options in a privately-held company, Research Funding; Global Blood Therapeutics: Consultancy, Ended employment in the past 24 months, Research Funding; Imara: Consultancy, Research Funding; Novartis: Consultancy, Research Funding; Forma Therapeutics: Research Funding. Kirkham:Global Blood Therapeutics/Pfizer: Other: Clinical trial activity.
[Display omitted]]]></description><identifier>ISSN: 0006-4971</identifier><identifier>EISSN: 1528-0020</identifier><identifier>DOI: 10.1182/blood-2023-188677</identifier><language>eng</language><publisher>Elsevier Inc</publisher><ispartof>Blood, 2023-11, Vol.142 (Supplement 1), p.3871-3871</ispartof><rights>2023 The American Society of Hematology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Bello-Manga, Halima</creatorcontrib><creatorcontrib>Nduba, Videlis</creatorcontrib><creatorcontrib>Abdullahi, Shehu Umar</creatorcontrib><creatorcontrib>Githanga, Jessie</creatorcontrib><creatorcontrib>Ogutu, Bernhards</creatorcontrib><creatorcontrib>El-Beshlawy, Amal M.</creatorcontrib><creatorcontrib>Hassab, Hoda MA</creatorcontrib><creatorcontrib>Badr, Mohamed</creatorcontrib><creatorcontrib>Tantawy, Azza</creatorcontrib><creatorcontrib>Brown, Biobele J</creatorcontrib><creatorcontrib>Paintsil, Vivian</creatorcontrib><creatorcontrib>Akinsete, Adeseye Michael</creatorcontrib><creatorcontrib>Segbefia, Catherine I.</creatorcontrib><creatorcontrib>Okpala, Iheanyi</creatorcontrib><creatorcontrib>Wali, Yasser</creatorcontrib><creatorcontrib>Essa, Mohammed</creatorcontrib><creatorcontrib>Farthing, Jason</creatorcontrib><creatorcontrib>Doss, Jennifer</creatorcontrib><creatorcontrib>Dixon, Sandy</creatorcontrib><creatorcontrib>Brown, Clark</creatorcontrib><creatorcontrib>Kirkham, Fenella</creatorcontrib><title>Transcranial Doppler Screening of Children with Sickle Cell Disease for a Large, Multinational Interventional Study: Experience from the Phase 3 HOPE-Kids 2 Trial Investigating the Effect of Voxelotor Treatment on Transcranial Doppler Flow Velocity</title><title>Blood</title><description><![CDATA[Introduction: Transcranial Doppler (TCD) ultrasound is an effective screening tool for identifying children with sickle cell disease (SCD) who are at high risk of stroke. Implementing TCD screening, along with appropriate therapies, for the purpose of primary stroke prevention in resource-constrained settings remains challenging. HOPE-KIDS 2 (NCT04218084) is an ongoing, phase 3, multicenter, double-blind, placebo-controlled trial of voxelotor in children with SCD and elevated arterial cerebral blood flow (measured by time-averaged maximum of the mean velocity [TAMMV]). Our aim is to describe the findings from successful implementation of a standardized TCD screening protocol that was conducted in a multinational setting.
Methods: The purpose of HOPE-KIDS 2 is to evaluate the effect of voxelotor treatment on reducing the risk of stroke in participants aged 2 to <15 years with SCD who have conditional TAMMV (170 to <200 cm/s) at baseline. Children aged 2 to <15 years with SCD (HbSS/HbSβ 0) were screened after local sonographers were trained and certified on standardized TCD examination protocol, using the same model of Multi-Dop T digital machine (Compumedics DWL, Germany). TCD assessments were sent for central quality review and interpretation by 2 independent reviewers. STOP criteria were used to classify stroke risk: normal, <170 cm/s; conditional, 170 to <200 cm/s; or abnormal, ≥200 cm/s. Patient baseline characteristics, including clinical measurements of markers of anemia and hemolysis, were measured during study screening. The reasons for patient screen failure were summarized.
Results: Between Nov 2020 and Feb 2023, 708 participants consented at 29 sites in Nigeria (n=250; 5 sites), Kenya (n=241; 4 sites), Egypt (n=145; 4 sites), Ghana (n=28; 2 sites), the US (n=17; 8 sites), Italy (n=9; 3 sites), Oman (n=9; 1 site), Saudi Arabia (n=8; 1 site), and the UK (n=1; 1 site). Of these patients, 92.1% (652/708) completed TCD screening examinations (mean [SD] age 7.6 [3.24] years; range 2.0-14.0 years; 50.8% male; 23.0% receiving hydroxyurea). Of the patients who completed TCD screening, the mean (SD) TAMMV was 163.0 (31.26) cm/s, and 47.1% (307/652) had conditional TCD at baseline (29.0% low conditional, 18.1% high conditional). The main reason for screen failure was index TAMMV outside of conditional range (abnormal, n=39 [6.0%]; normal, n=306 [46.9%]). Elevated TAMMV on screening TCD was more common in younger children (2 to ≤8 years vs >8 to <15 years); patients aged 2-8 years comprised 66.8% and 82.1% of the conditional and abnormal TCD categories, respectively. There were 39 assessments that required adjudication, but only 9 were deemed unreadable. Of all patients screened, 36.2% (236/652) fulfilled eligibility criteria for randomization; the characteristics at screening of these patients are summarized (Table). The mean (SD) Hb level and TAMMV at screening for randomly assigned patients was 7.7 (1.06) g/dL and 182.7 (7.53) cm/s, respectively.
Conclusions: Clinical sites for the HOPE-KIDS 2 study successfully implemented a standardized, local TCD screening protocol supported by central quality review. For a large interventional trial aimed at reducing the risk of stroke in children with SCD, African and Middle Eastern sites presented relatively few limitations with respect to participant screening.
Bello-Manga:Global Blood Therapeutics/Pfizer: Consultancy; Forma Therapeutics/Novo Nordisk: Other: Clinical trial activity; National Institutes of Health Fogarty International Center (K43TW011583): Research Funding. El-Beshlawy:Global Blood Therapeutics: Research Funding. Hassab:Global Blood Therapeutics: Research Funding. Wali:Global Blood Therapeutics: Honoraria, Research Funding. Farthing:Pfizer Inc: Current Employment, Current holder of stock options in a privately-held company; Global Blood Therapeutics: Ended employment in the past 24 months. Doss:Pfizer Inc: Current Employment, Current holder of stock options in a privately-held company; Global Blood Therapeutics: Ended employment in the past 24 months. Dixon:Pfizer Inc: Current Employment, Current holder of stock options in a privately-held company; Global Blood Therapeutics: Ended employment in the past 24 months. Brown:Pfizer Inc: Current Employment, Current holder of stock options in a privately-held company, Research Funding; Global Blood Therapeutics: Consultancy, Ended employment in the past 24 months, Research Funding; Imara: Consultancy, Research Funding; Novartis: Consultancy, Research Funding; Forma Therapeutics: Research Funding. Kirkham:Global Blood Therapeutics/Pfizer: Other: Clinical trial activity.
[Display omitted]]]></description><issn>0006-4971</issn><issn>1528-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9UU1vEzEQtVCRSAs_gNv8ALa198sbOKGQ0oqgVkrodeW1x4nBsSPbTZt_zhFv0mPFYTyy9N6bN_MI-cjoJWNdeTVY71VR0rIqWNe1nL8hE9aUXUFpSc_IhFLaFvWUs3fkPMbflLK6KpsJ-bsKwkWZHyMsfPO7ncUASxkQnXFr8BpmG2NVQAdPJm1gaeQfizBDm-EmoogI2gcQsBBhjZ_g56NNxolkvMuKty5h2KN7-S7Tozp8hvnzDoNBJzM3-C2kDcL9ZpSq4Obufl78MCpCCatgjhp7jMmss2Z2NGLnWqNMo7kH_4zWp2xgFVCkbZ4E3sGrW11b_wQPGS5NOrwnb7WwET-89Avy63q-mt0Ui7vvt7Ovi0KyivOCsRol1VS1zdBWnA681loNtBZVw0s-neZLylwCle5k2SKXjRA5kVpn-sCrC8JOujL4GAPqfhfMVoRDz2g_Rtcfo-vH6PpTdJnz5cTBbGxvMPRRHq-lTMh798qb_7D_AVq-poA</recordid><startdate>20231102</startdate><enddate>20231102</enddate><creator>Bello-Manga, Halima</creator><creator>Nduba, Videlis</creator><creator>Abdullahi, Shehu Umar</creator><creator>Githanga, Jessie</creator><creator>Ogutu, Bernhards</creator><creator>El-Beshlawy, Amal M.</creator><creator>Hassab, Hoda MA</creator><creator>Badr, Mohamed</creator><creator>Tantawy, Azza</creator><creator>Brown, Biobele J</creator><creator>Paintsil, Vivian</creator><creator>Akinsete, Adeseye Michael</creator><creator>Segbefia, Catherine I.</creator><creator>Okpala, Iheanyi</creator><creator>Wali, Yasser</creator><creator>Essa, Mohammed</creator><creator>Farthing, Jason</creator><creator>Doss, Jennifer</creator><creator>Dixon, Sandy</creator><creator>Brown, Clark</creator><creator>Kirkham, Fenella</creator><general>Elsevier Inc</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20231102</creationdate><title>Transcranial Doppler Screening of Children with Sickle Cell Disease for a Large, Multinational Interventional Study: Experience from the Phase 3 HOPE-Kids 2 Trial Investigating the Effect of Voxelotor Treatment on Transcranial Doppler Flow Velocity</title><author>Bello-Manga, Halima ; Nduba, Videlis ; Abdullahi, Shehu Umar ; Githanga, Jessie ; Ogutu, Bernhards ; El-Beshlawy, Amal M. ; Hassab, Hoda MA ; Badr, Mohamed ; Tantawy, Azza ; Brown, Biobele J ; Paintsil, Vivian ; Akinsete, Adeseye Michael ; Segbefia, Catherine I. ; Okpala, Iheanyi ; Wali, Yasser ; Essa, Mohammed ; Farthing, Jason ; Doss, Jennifer ; Dixon, Sandy ; Brown, Clark ; Kirkham, Fenella</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1377-114ec0f0d65b6370b74ffdb04a3572799001c001aedf8c26e7c5aa1824f377b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bello-Manga, Halima</creatorcontrib><creatorcontrib>Nduba, Videlis</creatorcontrib><creatorcontrib>Abdullahi, Shehu Umar</creatorcontrib><creatorcontrib>Githanga, Jessie</creatorcontrib><creatorcontrib>Ogutu, Bernhards</creatorcontrib><creatorcontrib>El-Beshlawy, Amal M.</creatorcontrib><creatorcontrib>Hassab, Hoda MA</creatorcontrib><creatorcontrib>Badr, Mohamed</creatorcontrib><creatorcontrib>Tantawy, Azza</creatorcontrib><creatorcontrib>Brown, Biobele J</creatorcontrib><creatorcontrib>Paintsil, Vivian</creatorcontrib><creatorcontrib>Akinsete, Adeseye Michael</creatorcontrib><creatorcontrib>Segbefia, Catherine I.</creatorcontrib><creatorcontrib>Okpala, Iheanyi</creatorcontrib><creatorcontrib>Wali, Yasser</creatorcontrib><creatorcontrib>Essa, Mohammed</creatorcontrib><creatorcontrib>Farthing, Jason</creatorcontrib><creatorcontrib>Doss, Jennifer</creatorcontrib><creatorcontrib>Dixon, Sandy</creatorcontrib><creatorcontrib>Brown, Clark</creatorcontrib><creatorcontrib>Kirkham, Fenella</creatorcontrib><collection>CrossRef</collection><jtitle>Blood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bello-Manga, Halima</au><au>Nduba, Videlis</au><au>Abdullahi, Shehu Umar</au><au>Githanga, Jessie</au><au>Ogutu, Bernhards</au><au>El-Beshlawy, Amal M.</au><au>Hassab, Hoda MA</au><au>Badr, Mohamed</au><au>Tantawy, Azza</au><au>Brown, Biobele J</au><au>Paintsil, Vivian</au><au>Akinsete, Adeseye Michael</au><au>Segbefia, Catherine I.</au><au>Okpala, Iheanyi</au><au>Wali, Yasser</au><au>Essa, Mohammed</au><au>Farthing, Jason</au><au>Doss, Jennifer</au><au>Dixon, Sandy</au><au>Brown, Clark</au><au>Kirkham, Fenella</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transcranial Doppler Screening of Children with Sickle Cell Disease for a Large, Multinational Interventional Study: Experience from the Phase 3 HOPE-Kids 2 Trial Investigating the Effect of Voxelotor Treatment on Transcranial Doppler Flow Velocity</atitle><jtitle>Blood</jtitle><date>2023-11-02</date><risdate>2023</risdate><volume>142</volume><issue>Supplement 1</issue><spage>3871</spage><epage>3871</epage><pages>3871-3871</pages><issn>0006-4971</issn><eissn>1528-0020</eissn><abstract><![CDATA[Introduction: Transcranial Doppler (TCD) ultrasound is an effective screening tool for identifying children with sickle cell disease (SCD) who are at high risk of stroke. Implementing TCD screening, along with appropriate therapies, for the purpose of primary stroke prevention in resource-constrained settings remains challenging. HOPE-KIDS 2 (NCT04218084) is an ongoing, phase 3, multicenter, double-blind, placebo-controlled trial of voxelotor in children with SCD and elevated arterial cerebral blood flow (measured by time-averaged maximum of the mean velocity [TAMMV]). Our aim is to describe the findings from successful implementation of a standardized TCD screening protocol that was conducted in a multinational setting.
Methods: The purpose of HOPE-KIDS 2 is to evaluate the effect of voxelotor treatment on reducing the risk of stroke in participants aged 2 to <15 years with SCD who have conditional TAMMV (170 to <200 cm/s) at baseline. Children aged 2 to <15 years with SCD (HbSS/HbSβ 0) were screened after local sonographers were trained and certified on standardized TCD examination protocol, using the same model of Multi-Dop T digital machine (Compumedics DWL, Germany). TCD assessments were sent for central quality review and interpretation by 2 independent reviewers. STOP criteria were used to classify stroke risk: normal, <170 cm/s; conditional, 170 to <200 cm/s; or abnormal, ≥200 cm/s. Patient baseline characteristics, including clinical measurements of markers of anemia and hemolysis, were measured during study screening. The reasons for patient screen failure were summarized.
Results: Between Nov 2020 and Feb 2023, 708 participants consented at 29 sites in Nigeria (n=250; 5 sites), Kenya (n=241; 4 sites), Egypt (n=145; 4 sites), Ghana (n=28; 2 sites), the US (n=17; 8 sites), Italy (n=9; 3 sites), Oman (n=9; 1 site), Saudi Arabia (n=8; 1 site), and the UK (n=1; 1 site). Of these patients, 92.1% (652/708) completed TCD screening examinations (mean [SD] age 7.6 [3.24] years; range 2.0-14.0 years; 50.8% male; 23.0% receiving hydroxyurea). Of the patients who completed TCD screening, the mean (SD) TAMMV was 163.0 (31.26) cm/s, and 47.1% (307/652) had conditional TCD at baseline (29.0% low conditional, 18.1% high conditional). The main reason for screen failure was index TAMMV outside of conditional range (abnormal, n=39 [6.0%]; normal, n=306 [46.9%]). Elevated TAMMV on screening TCD was more common in younger children (2 to ≤8 years vs >8 to <15 years); patients aged 2-8 years comprised 66.8% and 82.1% of the conditional and abnormal TCD categories, respectively. There were 39 assessments that required adjudication, but only 9 were deemed unreadable. Of all patients screened, 36.2% (236/652) fulfilled eligibility criteria for randomization; the characteristics at screening of these patients are summarized (Table). The mean (SD) Hb level and TAMMV at screening for randomly assigned patients was 7.7 (1.06) g/dL and 182.7 (7.53) cm/s, respectively.
Conclusions: Clinical sites for the HOPE-KIDS 2 study successfully implemented a standardized, local TCD screening protocol supported by central quality review. For a large interventional trial aimed at reducing the risk of stroke in children with SCD, African and Middle Eastern sites presented relatively few limitations with respect to participant screening.
Bello-Manga:Global Blood Therapeutics/Pfizer: Consultancy; Forma Therapeutics/Novo Nordisk: Other: Clinical trial activity; National Institutes of Health Fogarty International Center (K43TW011583): Research Funding. El-Beshlawy:Global Blood Therapeutics: Research Funding. Hassab:Global Blood Therapeutics: Research Funding. Wali:Global Blood Therapeutics: Honoraria, Research Funding. Farthing:Pfizer Inc: Current Employment, Current holder of stock options in a privately-held company; Global Blood Therapeutics: Ended employment in the past 24 months. Doss:Pfizer Inc: Current Employment, Current holder of stock options in a privately-held company; Global Blood Therapeutics: Ended employment in the past 24 months. Dixon:Pfizer Inc: Current Employment, Current holder of stock options in a privately-held company; Global Blood Therapeutics: Ended employment in the past 24 months. Brown:Pfizer Inc: Current Employment, Current holder of stock options in a privately-held company, Research Funding; Global Blood Therapeutics: Consultancy, Ended employment in the past 24 months, Research Funding; Imara: Consultancy, Research Funding; Novartis: Consultancy, Research Funding; Forma Therapeutics: Research Funding. Kirkham:Global Blood Therapeutics/Pfizer: Other: Clinical trial activity.
[Display omitted]]]></abstract><pub>Elsevier Inc</pub><doi>10.1182/blood-2023-188677</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| title | Transcranial Doppler Screening of Children with Sickle Cell Disease for a Large, Multinational Interventional Study: Experience from the Phase 3 HOPE-Kids 2 Trial Investigating the Effect of Voxelotor Treatment on Transcranial Doppler Flow Velocity |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T02%3A56%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-elsevier_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Transcranial%20Doppler%20Screening%20of%20Children%20with%20Sickle%20Cell%20Disease%20for%20a%20Large,%20Multinational%20Interventional%20Study:%20Experience%20from%20the%20Phase%203%20HOPE-Kids%202%20Trial%20Investigating%20the%20Effect%20of%20Voxelotor%20Treatment%20on%20Transcranial%20Doppler%20Flow%20Velocity&rft.jtitle=Blood&rft.au=Bello-Manga,%20Halima&rft.date=2023-11-02&rft.volume=142&rft.issue=Supplement%201&rft.spage=3871&rft.epage=3871&rft.pages=3871-3871&rft.issn=0006-4971&rft.eissn=1528-0020&rft_id=info:doi/10.1182/blood-2023-188677&rft_dat=%3Celsevier_cross%3ES0006497123104733%3C/elsevier_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rft_els_id=S0006497123104733&rfr_iscdi=true |