CEBPA-Driven Expression of the Transcriptionally Inactive deltaTP73 Isoform Phenocopies TP53 mutated Poor Risk and Drug-Resistant Acute Myeloid Leukemia

Mutations in TP53 ( TP53mut) are present in roughly 10% of acute myeloid leukemia (AML) patients and represent a unique subgroup of patients with very poor prognosis. While the exact mechanisms of TP53mut-driven leukemogenesis remain elusive, transcriptional changes associated with suppression of th...

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Veröffentlicht in:	Blood 2023-11, Vol.142 (Supplement 1), p.839-839
Hauptverfasser:	Pereira-Martins, Diego, Ortiz Rojas, César Alexander, Weinhaeuser, Isabel, Wierenga, Bart-Jan, Van Den Boom, Vincent, Mojallali, Fatemeh, Sternadt, Dominique, Bianco, Thiago Mantello, van der Meer, Nisha, Silveira, Douglas RA, Quek, Lynn, Ammatuna, Emanuele, Lucena-Araujo, Antonio R, Huls, Gerwin A., Rego, Eduardo Magalhães, Schuringa, Jan Jacob
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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