$A First-in-Human, Phase 1, Dose Escalation Study of Sgr-2921 As Monotherapy in Subjects with Relapsed/Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome$

A First-in-Human, Phase 1, Dose Escalation Study of Sgr-2921 As Monotherapy in Subjects with Relapsed/Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome

Background Cell division cycle 7-related protein kinase (CDC7), or DBF4-dependent CDC7 kinase (DDK), is a cell cycle kinase that maintains DNA replication by phosphorylation and activation of the minichromosome maintenance protein 2 and 4 (MCMs), components of the replicative DNA helicase. Due to th...

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Veröffentlicht in:	Blood 2023-11, Vol.142 (Supplement 1), p.1548-1548
Hauptverfasser:	DiNardo, Courtney D., Strickland, Stephen Anthony, Skikne, Barry, Zeidan, Amer M., Traer, Elie, Carraway, Hetty E., Frankel, Stanley, Weiss, Daniel E, Wang, Jacky H, Pirie-Shepherd, Steven, Piccotti, Joseph, Wright, D. Hamish, Akinsanya, Karen
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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