Poor Hematopoietic Reserve at the Time of CD19 CAR T-Cell Infusion Is Associated with Long Term B-Cell Aplasia

Background: On-target off-tumor toxicities of anti-CD19 CAR T-cell therapy include B-cell aplasia and hypogammaglobulinemia. Long term B-cell aplasia is hypothesized to represent functional CAR T-cell engraftment (Melenhorst, Nature 2022), while peripheral blood B-cell recovery represents the loss o...

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Veröffentlicht in:	Blood 2023-11, Vol.142 (Supplement 1), p.3512-3512
Hauptverfasser:	Johnson, Grace, Patel, Kedar, Arciola, Brian, Perez Perez, Ariel, Wood, Anthony, Ionescu, Filip, Logue, Jennifer M, Albanyan, Omar, Yasin, Hassaan, Bachmeier, Christina A, Reid, Kayla, Menges, Meghan, Corallo, Salvatore, Shah, Bijal D., Chavez, Julio C, Khimani, Farhad, Nishihori, Taiga, Faramand, Rawan, Liu, Hien, Lazaryan, Aleksandr, Rejeski, Kai, Subklewe, Marion, Perna, Fabiana, Davila, Marco, Mhaskar, Rahul, Locke, Frederick L., Jain, Michael D.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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