Lipid Nanoparticle-Mediated Gene Editing of Human Primary T Cells and Off-Target Analysis of the CRISPR-Cas9 Indels

Background and Aims: The CRISPR/Cas9 system has emerged as a powerful tool for gene editing of primary cells. In our previous work, we demonstrated a novel lipid nanoparticle (LNP) reagent for the multi-step engineering of gene-edited CAR T cells. We showed high cell viabilities and potent CAR-T med...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Blood 2023-11, Vol.142 (Supplement 1), p.6833-6833
Hauptverfasser:	Geczy, Reka, Thommandru, Bernice, Swaminathan, Meenakshi, Zhao, Rita, Tan, Krystal, Low, Kevin, Balgi, Aruna, Park, Stella, Watt, Ethan, Thada, Vaughn, Rettig, Garrett, Zhang, Angela, Turk, Rolf, Clarke, Samuel
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!