Clinical Impact of Neoantigen Burden and HLA Loss in Aggressive B-Cell Lymphomas Treated with CD19 CAR T-Cell

INTRODUCTION: CD19-directed chimeric antigen receptor (CAR-19) T cells have revolutionized clinical outcomes in heavily pretreated patients with aggressive B-cell lymphoma. Notably, emerging evidence suggests that the efficacy of CAR-19 therapy extends beyond direct tumor killing and includes its ab...

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Veröffentlicht in:	Blood 2023-11, Vol.142 (Supplement 1), p.4362-4362
Hauptverfasser:	Ziccheddu, Bachisio, Jain, Michael D., Chojnacka, Monika, Durante, Michael, Abraham Miranda, Julieta, Menges, Meghan, Landgren, Ola, Davila, Marco, Schatz, Jonathan H., Maura, Francesco, Locke, Frederick L.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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