Single-Cell RNA-Seq Reveals Intermediate Cell States and Identifies Features Defining Cellular Heterogeneity in Inv(16) Acute Myeloid Leukemia (AML)

AML is an aggressive hematological malignancy with heterogeneous genetic abnormalities. One recurrent chromosomal translocation common in AML is chromosome 16 inversion, inv(16)(p13.1q22), which results in the leukemogenic fusion gene CBFB- MYH11. Using a conditional Cbfb-MYH11 (CM) knock-in mouse m...

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Veröffentlicht in:	Blood 2023-11, Vol.142 (Supplement 1), p.5683-5683
Hauptverfasser:	Fu, Yu-Hsuan, Zhang, Lianjun, Chen, Ying-Chieh, Frankhouser, David, Uechi, Lisa, O'Meally, Denis, Branciamore, Sergio, Marcucci, Guido, Rockne, Russell C., Kuo, Ya-Huei
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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