Low Target Antigen Expression Mediates Resistance to BCMA CAR T Cell Therapy

Introduction: BCMA-targeted CAR T cell therapies have shown promising responses, but many patients have residual disease post therapy, and relapses are common. Prior studies with CD19-targeted CAR T cells have shown that antigen density is an important determinant of response, with CARs requiring se...

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Veröffentlicht in:	Blood 2023-11, Vol.142 (Supplement 1), p.2124-2124
Hauptverfasser:	Perica, Karlo, Nataraj, Sarah, Sjojstrand, Maria Lemdal, Nagel, Katherine, Pavkovic, Emma, Payson, Erica, Cuenca, Ana, Patel, Anjali, Chung, David, Mailankody, Sham, Shah, Gunjan L., Usmani, Saad Z, Giralt, Sergio A., Sadelain, Michel
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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