Reshaping MRD Detection Strategies: Next-Generation Sequencing and High DNA Input Identify Previously Missed Measurable Residual Disease in Peripheral Blood of B-Cell Precursor Acute Lmyphoblastic Leukemia

Background: In acute lymphoblastic leukemia (ALL), measurable residual disease (MRD) is the most important prognostic factor. MRD is traditionally quantified in bone marrow aspirates (BM) using real-time quantitative polymerase chain reaction (RQ-PCR) according to EuroMRD standards. Since the emerge...

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Veröffentlicht in:	Blood 2023-11, Vol.142 (Supplement 1), p.4354-4354
Hauptverfasser:	Bendig, Sonja, Bufe, Sandra, Fricke, Birgit, Proske, Constantin, Darzentas, Nikos, Kehden, Britta, Chitadze, Guranda, Baldus, Claudia D, Kotrova, Michaela, Goekbuget, Nicola, Brüggemann, Monika
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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