Integrated Genomic Analysis Identifies UBTF Tandem Duplications As a Subtype-Defining Lesion in Pediatric Acute Myeloid Leukemia

Children with acute myeloid leukemia (AML) have a dismal prognosis due to a high relapse rate; however, the molecular basis leading to relapsed pediatric AML has not yet been fully characterized. To define the spectrum of alterations common at relapse, we performed integrated profiling of 136 relaps...

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Veröffentlicht in:	Blood 2021-12, Vol.138 (Supplement 2), p.LBA-4-LBA-4
Hauptverfasser:	Umeda, Masayuki, Ma, Jing, Huang, Benjamin J., Hagiwara, Kohei, Westover, Tamara, Abdelhamed, Sherif, Barajas, Juan Martin, Thomas, Melvin Edward, Walsh, Michael P, Song, Guangchun, Tian, Liqing, Liu, Yanling, Chen, Xiaolong, Kolekar, Pandurang, Tran, Quang, Foy, Scott, Maciaszek, Jamie L., Kleist, Andrew B, Leonti, Amanda R., Ju, Bensheng, Easton, John, Wu, Huiyun, Valentine, Virginia, Valentine, Marc, Liu, Yen-Chun, Ries, Rhonda E., Smith, Jenny L., Parganas, Evan, Iacobucci, Ilaria, Hiltenbrand, Ryan, Miller, Jonathan, Myers, Jason, Rampersaud, Evadnie, Rahbarinia, Delaram, Rusch, Michael, Wu, Gang, Inaba, Hiroto, Wang, Yi-Cheng, Alonzo, Todd A., Downing, James R., Mullighan, Charles G., Pounds, Stanley B, Babu, M. Madan, Zhang, Jinghui, Rubnitz, Jeffrey E., Meshinchi, Soheil, Ma, Xiaotu, Klco, Jeffery M.
Format:	Artikel
Sprache:	eng
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