Phase 1b Trial of Talazoparib and Gemtuzumab Ozogamicin in Adult Patients with CD33+ Relapsed or Refractory Acute Myeloid Leukemia

Background: Poly (ADP-ribose) polymerase (PARP) enzymes are involved in repair of single-strand DNA breaks through base excision repair pathways. Inhibitors of PARP are approved for the treatment of BRCA1/2-mutant malignancies. We have previously demonstrated (Portwood et al, ASH 2019 abstract) that...

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Veröffentlicht in:	Blood 2021-11, Vol.138 (Supplement 1), p.4435-4435
Hauptverfasser:	Swaminathan, Mahesh, Przespolewski, Amanda, Griffiths, Elizabeth A., Thompson, James E., Elshoury, Amro, Walinski, Wendy, Said, Meriem, Halliwell, Stephanie, Puff, Claire, Attwood, Kristopher, Wang, Eunice S.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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