Clonal Hematopoiesis in Telomere Biology Disorders Associates with the Underlying Germline Defect and Somatic Mutations in POT1, PPM1D, and TERT promoter

Introduction: Telomere biology (TBD) disorders are caused by pathogenic germline variants in genes related to telomere maintenance. In TBD, clonal hematopoiesis (CH) has been hypothesized to compensate for restricted cell fitness and to lead to development of myelodysplastic syndromes and acute myel...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Blood 2021-11, Vol.138 (Supplement 1), p.1111-1111
Hauptverfasser:	Gutierrez-Rodrigues, Fernanda, Groarke, Emma M, Clé, Diego V, Patel, Bhavisha A., Donaires, Flávia S, Spitofsky, Nina, Alemu, Lemlem, Santana, Bárbara A, Kajigaya, Sachiko, Colla, Simona, De Oliveira, Michel Michels, Bonfim, Carmem M.S., Calado, Rodrigo T., Young, Neal S.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!