Multi-Recombinase Mouse Models of Flt3-Driven Leukemia Identifies Distinct Trajectories of Mutational Cooperativity and Leukemic Transformation

Genomic studies in acute myeloid leukemia (AML) have generated a near complete catalogue of genes mutated at varying frequencies both across patients and in individual leukemias. The high variability of mutation burden within a given leukemia is suggestive of a stepwise evolutionary process composed...

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Veröffentlicht in:	Blood 2021-11, Vol.138 (Supplement 1), p.2220-2220
Hauptverfasser:	Bowman, Robert L., Mishra, Tanmay, Eisman, Shira E., Cai, Louise, Xiao, Wenbin, Waarts, Michael R., Sanchez Vela, Pablo, Fernández-Maestre, Inés, Csete, Isabelle S., Potts, Chad R., Jenkins, Matthew T., Miles, Linde A., Trowbridge, Jennifer J., Ferrell, Paul Brent, Levine, Ross L.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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