Multiomic Mapping of Copy Number and Structural Variation on Chromosome 1 (Chr1) Highlights Multiple Recurrent Disease Drivers

Introduction Copy number abnormalities (CNA) and structural variants (SV) are crucial to driving cancer progression and in multiple myeloma (MM). Chr1 CNA are seen in up to 40% of cases and associate with poor prognosis. Variants include deletions, gains, translocations and complex SV events such as...

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Veröffentlicht in:	Blood 2021-11, Vol.138 (Supplement 1), p.721-721
Hauptverfasser:	Blaney, Patrick, Boyle, Eileen M, Wang, Yubao, Ghamlouch, Hussein, Choi, Jinyoung, Williams, Louis, James, Stoeckle, Siegel, Ariel, Razzo, Beatrice, Braunstein, Marc, Kaminetzky, David, Arbini, Arnaldo A, Bruno, Benedetto, Corre, Jill, Montes, Lydia, Auclair, Daniel, Davies, Faith E., Tsirigos, Aristotelis, Rustad, Even H, Maura, Francesco, Landgren, Ola, Bauer, Michael A, Walker, Brian, Morgan, Gareth
Format:	Artikel
Sprache:	eng
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