$High-Dose Carfilzomib Recaptures Response in Relapsed/Refractory Multiple Myeloma Resistant to Low-Dose Carfilzomib By Co-Inhibiting β2 Subunit of Proteasome Complex: The First in Human Evidence$

High-Dose Carfilzomib Recaptures Response in Relapsed/Refractory Multiple Myeloma Resistant to Low-Dose Carfilzomib By Co-Inhibiting β2 Subunit of Proteasome Complex: The First in Human Evidence

Background Proteasome, a complex involved in the intracellular protein degradation, consists of multiple subunits, but only three subunits have enzymatic activity to cleave and degrade proteins, namely β1, β2 and β5. Carfilzomib (CFZ), a second-generation proteasome inhibitor (PI), can induce cell d...

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Veröffentlicht in:	Blood 2021-11, Vol.138 (Supplement 1), p.818-818
Hauptverfasser:	Zhou, Xiang, Besse, Andrej, Peter, Jessica, Mendez Lopez, Max, Haertle, Larissa, Munawar, Umair, Han, Seungbin, Maurits, Elmer, Overkleeft, Herman S., Einsele, Hermann, Driessen, Christoph, Kortuem, Martin, Besse, Lenka, Rasche, Leo
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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