Oncogenic SETBP1 Mutations Combine with Activating Mutations in CSF3R to Produce a Highly Proliferative, Lethal Leukemia through Aberrant Myc Signaling

SETBP1 (SET Binding Protein 1) mutations are associated with exceptionally poor prognosis in myeloid neoplasms. Despite this, SETBP1's role in oncogenesis remains incompletely understood. In this study, we find that SETBP1 leads to a marked upregulation of the Myc oncogene and associated pro-st...

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Veröffentlicht in:	Blood 2020-11, Vol.136 (Supplement 1), p.51-52
Hauptverfasser:	Carratt, Sarah A, Braun, Theodore P., Schonrock, Zachary, Smith, Brittany M., Coleman, Daniel J, Kong, Garth, Estabrook, Joseph, Baris, Adrian, Maloney, Lauren, Maxson, Julia E.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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