High-Resolution Binding Atlas of U2AF1 Mutants Uncovers New Complexity in Splicing Alterations and Kinetics in Myeloid Malignancies

Spliceosomal gene mutations function as drivers of hematologic malignancies and other cancers with an occurrence of more than 50% in myelodysplastic syndromes and secondary acute myeloid leukemia. Hotspot mutations S34F and Q157R in the two zinc finger domains of the splicing factor U2AF1, forming w...

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Veröffentlicht in:	Blood 2020-11, Vol.136 (Supplement 1), p.3-4
Hauptverfasser:	Biancon, Giulia, Joshi, Poorval, Hunck, Torben, Zimmer, Josh, Gao, Yimeng, Machyna, Martin, Botti, Valentina, Qin, Ashley, Viero, Gabriella, Neuenkirchen, Nils, Taylor, Ashley, Gbyli, Rana, Patel, Amisha, Ardasheva, Anastasia, Fu, Xiaoying, Lin, Haifan, Simon, Matthew D, Neugebauer, Karla M, Tebaldi, Toma, Halene, Stephanie
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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