Imetelstat Inhibits Telomerase and Prevents Propagation of ADAR1-Activated Myeloproliferative Neoplasm and Leukemia Stem Cells

BACKGROUND Clonal stem cell derived myeloproliferative neoplasms (MPNs) have a propensity to evolve to acute myeloid leukemia (AML). Deregulation of the innate immune deaminase associated with RNA1 (ADAR1) has been linked to malignant progression and therapeutic resistance. Increased expression of t...

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Veröffentlicht in:	Blood 2020-11, Vol.136 (Supplement 1), p.18-18
Hauptverfasser:	Ma, Wenxue, Balaian, Larissa, Mondala, Phoebe, He, Yudou, Mason, Cayla, Pham, Jessica, Lee, Jeremy, Diep, Raymond, Coso, Sanja, Fisch, Kathleen, Mark, Adam, Morris, Sheldon, Jiang, Qingfei, Whisenant, Thomas, Rizo, Aleksandra, Huang, Fei, Donohoe, Mary, Alexandrov, Ludmil, Jamieson, Catriona
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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