Safety and Antitumor Effects of CD19-Specific Autologous Chimeric Antigen Receptor-Modified T (CAR-T) Cells Expressing the Inducible Caspase 9 Safety Switch (iC9-CAR19 T Cells) in Adult Acute Lymphoblastic Leukemia (ALL)

Introduction: CAR-T cells targeting the CD19 antigen are approved to treat children and young adults with relapsed and refractory B-cell ALL, in whom response rates are >80%. Acute toxicities, including cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (IC...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Blood 2020-11, Vol.136 (Supplement 1), p.36-37
Hauptverfasser:	Foster, Matthew C, Roehrs, Philip A., Hucks, George E, Grover, Natalie S, Armistead, Paul M., Jamieson, Katarzyna, Buchanan, Faith Brianne, Morrison, J. Kaitlin C, Laing, Spencer, Cheng, Catherine Joyce Arago, Serody, Jonathan S., Dotti, Gianpietro, Savoldo, Barbara
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!