FLT3 Inhibitors Induce Instability of p53 By Mir-181 Mediated Downregulation of Deubiquitinase YOD1 in Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a hematological malignancy featured by impaired differentiation and uncontrolled proliferation of myeloid blasts. FLT3 internal tandem duplication (ITD) presents in 30-40% patients with AML, which serves as an independent poor prognostic marker and an attractive thera...

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Veröffentlicht in:	Blood 2020-11, Vol.136 (Supplement 1), p.6-7
Hauptverfasser:	Pei, Han Zhong, Guo, Yao, Lu, Bo, Chang, Zhiguang, Zhang, Dengyang, Yu, Liuting, Zhao, Yuming, Baek, Suk-Hwan, Chen, Yun, Zhao, Zhizhuang Joe
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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