JAK inhibition for murine HLH requires complete blockade of IFN-γ signaling and is limited by toxicity of JAK2 inhibition

Hemophagocytic lymphohistiocytosis (HLH) is an inflammatory disorder in which numerous cytokines are elevated, though interferon-γ (IFN-γ) is central to disease pathogenesis and a key therapeutic target. Experimental and early clinical reports have shown that ruxolitinib, a small molecule inhibitor...

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Veröffentlicht in:	Blood 2021-09, Vol.138 (12), p.1034-1039
Hauptverfasser:	Chaturvedi, Vandana, Lakes, Nora, Tran, Minh, Castillo, Natalie, Jordan, Michael B.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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