Blocking Vascular Niche E-Selectin Dampens AML Stem Cell Regeneration/Survival Potential In Vivo By Inhibiting MAPK/ERK and PI3K/AKT Signalling Pathways

We have previously shown vascular E (endothelial)-selectin to play a key role in niche-mediated chemo-resistance in Acute Myeloid Leukaemia (AML). Now we report that the cell surface glycosylation of AML blasts -and thus their E-selectin-binding potential- alters during therapy and queried whether t...

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Veröffentlicht in:	Blood 2019-11, Vol.134 (Supplement_1), p.2657-2657
Hauptverfasser:	Winkler, Ingrid G, Barbier, Valerie, Tay, Joshua, Levesque, Jean-Pierre, Magnani, John L., Fiveash, Corrine E, Erbani, Johanna D
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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