Generation, Characterization and Pre-Clinical Drug Evaluation of Patient-Derived Xenograft Models of Pediatric Down Syndrome AML

Children with Down syndrome (DS) are at a 500-fold increased risk for developing acute myeloid leukemia (AML) before they reach five years of age. DS-AML blasts have hypersensitivity to chemotherapeutic drugs such as cytarabine and daunorubicin. However, therapy-induced toxicity results in greater m...

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Veröffentlicht in:	Blood 2019-11, Vol.134 (Supplement_1), p.2683-2683
Hauptverfasser:	Barwe, Sonali, Kolb, E. Anders, Crowgey, Erin Lynn, Druley, Todd E, Gopalakrishnapillai, Anilkumar
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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