A Novel Class of Bifunctional Immunotherapeutic That Exploits a Universal Antibody Binding Terminus (uABT) to Recruit Endogenous Antibodies to Cell Expressing CD38 Demonstrate In Vivo efficacy in Three Distinct Animal Models

Background: Antibody recruiting molecules (ARM) represent a new modality in immunotherapy of cancer. These are bifunctional molecules composed of two active termini connected by a linker. One of the termini binds to a target molecule on a cancer cell. The other terminus can recruit endogenous IgG an...

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Veröffentlicht in:	Blood 2019-11, Vol.134 (Supplement_1), p.1820-1820
Hauptverfasser:	Bunin, Anna, McGrath, Katy, Rossi, Ann Marie, Welsch, Matthew, Vidal, Christian, Trinh, David, Spiegel, David, Rastelli, Luca, Alvarez, Enrique
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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