The Prolonged Inhibition of Chk1/Chk2 Kinases Enhances Genetic Instability and Compromises the Efficacy of Chemotherapy Against Acute Lymphoblastic Leukemia Cells

Acute lymphoblastic leukemia (ALL) cells respond to chemotherapy, or more generally to DNA damages, by activating different DNA Damage Response (DDR) pathways. DDR-pathways regulate cell cycle progression and DNA damages repair. Molecular and functional alterations in key DDR-related genes drastical...

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Veröffentlicht in:	Blood 2019-11, Vol.134 (Supplement_1), p.5047-5047
Hauptverfasser:	Ghelli Luserna Di Rorà, Andrea, Padella, Antonella, Fontana, Maria Chiara, Fonzi, Eugenio, Ferrari, Anna, Imbrogno, Enrica, Ghetti, Martina, Napolitano, Roberta, Bochicchio, Maria Teresa, Martinelli, Giovanni, Simonetti, Giorgia
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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