TGF-β Signaling Contributes to Myelofibrosis and Clonal Dominance of Myeloproliferative Neoplasms

TGF-β expression is elevated in most cases of myeloproliferative neoplasms (MPNs). However, the contribution of TGF-β to disease pathogenesis is not well understood. Prior studies have shown that TGF-β regulates hematopoietic stem cell (HSC) quiescence. There also is published evidence that increase...

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Veröffentlicht in:	Blood 2019-11, Vol.134 (Supplement_1), p.470-470
Hauptverfasser:	Yao, Juo-Chin, Abou Ezzi, Grazia, Krambs, Joseph R., Uttarwar, Salil, Duncavage, Eric J., Link, Daniel C.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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