Targeted Marrow Radiation (TMI) Improves Therapeutic Efficacy of STAT3 Decoy Molecules By Augmenting Its Delivery and Immune Modulation in an AML Mouse Model

Targeted Marrow Radiation (TMI) Improves Therapeutic Efficacy of STAT3 Decoy Molecules By Augmenting Its Delivery and Immune Modulation in an AML Mouse Model

Introduction Acute myeloid leukemia (AML) is a highly aggressive form of leukemia with poor long-term survival. Our clinical development of a targeted radiation treatment for relapsed/refractory AML disease led to an impressive two-year overall survival (OS) rate of 41% (Stein et al., 2019) in contr...

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Veröffentlicht in:Blood 2019-11, Vol.134 (Supplement_1), p.3929-3929
Hauptverfasser: Sargur Madabushi, Srideshikan, Zuro, Darren, SU, Yu-Lin, Vishwasrao, Paresh, Brooks, Jamison, E Parra, Liliana, Sanchez, James F, Wong, Jeffrey, Kortylewski, Marcin, Hui, Susanta
Format: Artikel
Sprache:eng
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Zusammenfassung:Introduction Acute myeloid leukemia (AML) is a highly aggressive form of leukemia with poor long-term survival. Our clinical development of a targeted radiation treatment for relapsed/refractory AML disease led to an impressive two-year overall survival (OS) rate of 41% (Stein et al., 2019) in contrast to
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2019-127470