A Single Dose of CD117 Antibody Drug Conjugate Enables Autologous Gene-Modified Hematopoietic Stem Cell Transplant (Gene Therapy) in Nonhuman Primates

Autologous hematopoietic stem cell transplantation (Auto-HSCT) with gene-modification techniques represents a potential cure for multiple genetic blood diseases. Despite its broad curative potential, auto-gene modified HSCT is currently limited due to morbidity/mortality from cytotoxic chemotherapy-...

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Veröffentlicht in:	Blood 2019-11, Vol.134 (Supplement_1), p.610-610
Hauptverfasser:	Tisdale, John F., Donahue, Robert E., Uchida, Naoya, Pearse, Bradley R, McDonough, Sean M, Proctor, Jennifer L, Krouse, Allen, Linde, Nathaniel S., Bonifacino, Aylin C., Panwar, Rajiv, Sarma, Ganapathy N., Kien, Lena, Latimer, Kellie, Dushime, Junia, Hyzy, Sharon L., Brooks, Melissa L., Palchaudhuri, Rahul, Li, Qing, Sawant, Pranoti, McDonagh, Charlotte F, Boitano, Anthony E., Cooke, Michael P.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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