Mechanistic Basis and Efficacy of Targeting β-Catenin-TCF7L2-JMJD6-MYC Axis to Overcome Resistance to BET Inhibitors

Hematopoietic progenitor cells of myeloproliferative neoplasms with myelofibrosis (MPN-MF) exhibit constitutive activation of JAK-STAT5/3 and NFkB signaling. Transformation of MPN-MF to AML (post-MPN sAML) occurs in up to 15% of patients with MPN-MF. Standard induction anti-AML chemotherapy and the...

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Veröffentlicht in:	Blood 2019-11, Vol.134 (Supplement_1), p.538-538
Hauptverfasser:	Mill, Christopher Peter, Fiskus, Warren, Saenz, Dyana T., Lara, Bernardo H, Karkhanis, Vrajesh, Manshouri, Taghi, Bhalla, Isean, Shao, Nancy, Maher, James V, Verstovsek, Srdan, Bhalla, Kapil N.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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