Generation and Characterisation of KY1066, a Fully Human Antibody Targeting the Enzymatic Activity of Matriptase-2 for the Treatment of Iron Overload in Beta Thalassemia

Beta thalassemia is an inherited hemoglobinopathy caused by a genetic defect in beta-globin gene and characterised by ineffective erythropoiesis, iron overload, splenomegaly and anemia. Excessive EPO production, resulting from the anemia, has a suppressive effect on the iron regulator hepcidin leadi...

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Veröffentlicht in:	Blood 2019-11, Vol.134 (Supplement_1), p.3532-3532
Hauptverfasser:	Wake, Matthew, Papworth, Jonathan, Bayliss, Luke, Grimshaw, Benjamin, Rynkiewicz, Natalie, Paterson, Jemima, Poindron, Alicia, Spearing, Erin, Carter, Emily, Hudson, Robyne, Petzer, Verena, Largounez, Amelie, Belot, Audrey, Palin, Anais, Theurl, Igor, Germaschewski, Volker, Meynard, Delphine
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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