PPM1D and DNMT3A Mutations in Myelodysplasia and Clonal Hematopoiesis

Introduction: Age-related clonal hematopoiesis (CH) has been implicated in an increased risk of myeloid neoplasms. While common driver genes mutated in CH largely overlap to those in myeloid neoplasms, a notable exception is protein phosphatase Mg2+/Mn2+dependent 1D gene (PPM1D), encoding a p53-targ...

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Veröffentlicht in:	Blood 2019-11, Vol.134 (Supplement_1), p.1709-1709
Hauptverfasser:	Motomura, Masanori, Inoue, Yoshikage, Nagata, Yasunobu, Yoshizato, Tetsuichi, Baer, Constance, Momozawa, Yukihide, Nadarajah, Niroshan, Nannya, Yasuhito, Yoshida, Kenichi, Haferlach, Claudia, Kern, Wolfgang, Atsuta, Yoshiko, Iijima-Yamashita, Yuka, Shiraishi, Yuichi, Onizuka, Makoto, Chiba, Kenichi, Tanaka, Hiroko, Itonaga, Hidehiro, Miyazaki, Yasushi, Horibe, Keizo, Sanada, Masashi, Kamatani, Yoichiro, Kubo, Michiaki, Miyano, Satoru, Haferlach, Torsten, Ogawa, Seishi, Makishima, Hideki
Format:	Artikel
Sprache:	eng
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