Targeting aberrant DNA hypermethylation as a driver of ATL leukemogenesis by using the new oral demethylating agent OR-2100

Adult T-cell leukemia-lymphoma (ATL) is an aggressive hematological malignancy of CD4+ T cells transformed by human T-cell lymphotropic virus-1 (HTLV-1). Most HTLV-1–infected individuals are asymptomatic, and only 3% to 5% of carriers develop ATL. Here, we describe the contribution of aberrant DNA m...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Blood 2020-08, Vol.136 (7), p.871-884
Hauptverfasser:	Watanabe, Tatsuro, Yamashita, Satoshi, Ureshino, Hiroshi, Kamachi, Kazuharu, Kurahashi, Yuki, Fukuda-Kurahashi, Yuki, Yoshida, Nao, Hattori, Naoko, Nakamura, Hideaki, Sato, Akemi, Kawaguchi, Atsushi, Sueoka-Aragane, Naoko, Kojima, Kensuke, Okada, Seiji, Ushijima, Toshikazu, Kimura, Shinya, Sueoka, Eisaburo
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Aged Animals Antineoplastic Agents - administration & dosage Cell Transformation, Viral - drug effects Cell Transformation, Viral - genetics Cells, Cultured Demethylation - drug effects DNA Methylation - drug effects DNA Methylation - genetics Drugs, Investigational - therapeutic use Female Gene Expression Regulation, Leukemic - drug effects HTLV-I Infections - complications HTLV-I Infections - drug therapy HTLV-I Infections - genetics Human T-lymphotropic virus 1 - drug effects Human T-lymphotropic virus 1 - physiology Humans Leukemia-Lymphoma, Adult T-Cell - drug therapy Leukemia-Lymphoma, Adult T-Cell - genetics Mice Mice, Inbred BALB C Mice, Knockout Molecular Targeted Therapy - methods Pyridines - administration & dosage Xenograft Model Antitumor Assays Young Adult
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!