Ruxolitinib can cause weight gain by blocking leptin signaling in the brain via JAK2/STAT3

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Veröffentlicht in:	Blood 2020-03, Vol.135 (13), p.1062-1066
Hauptverfasser:	Mollé, Nicole, Krichevsky, Spencer, Kermani, Pouneh, Silver, Richard T., Ritchie, Ellen, Scandura, Joseph M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain - metabolism Humans Janus Kinase 2 - metabolism Leptin - metabolism Protein Kinase Inhibitors - adverse effects Pyrazoles - adverse effects Signal Transduction - drug effects STAT3 Transcription Factor - metabolism Weight Gain - drug effects
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doi_str_mv	10.1182/blood.2019003050
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source	MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection
subjects	Brain - metabolism Humans Janus Kinase 2 - metabolism Leptin - metabolism Protein Kinase Inhibitors - adverse effects Pyrazoles - adverse effects Signal Transduction - drug effects STAT3 Transcription Factor - metabolism Weight Gain - drug effects
title	Ruxolitinib can cause weight gain by blocking leptin signaling in the brain via JAK2/STAT3
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