Hematopoietic Stem Cell Transplantation in Children with Refractory Langerhans Cell Histiocytosis

Introduction Hematopoietic stem cell transplantation (HSCT) is one of the promising treatment strategies for children with refractory Langerhans cell histiocytosis (LCH), because of its immunomodulatory effects.Efficacy and indication of HSCT has been still undetermined. We analyzed the outcomes of...

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Veröffentlicht in:Blood 2018-11, Vol.132 (Supplement 1), p.4657-4657
Hauptverfasser: Kudo, Kazuko, Maeda, Miho, Suzuki, Nobuhiro, Kanegane, Hirokazu, Ohga, Shouichi, Ishii, Eiichi, Shioda, Yoko, Imamura, Toshihiko, Imashuku, Shinsaku, Tsunematsu, Yukiko, Endo, Mikiya, Shimada, Akira, Koga, Yuuki, Hashii, Yoshiko, Inagaki, Jiro, Inoue, Masami, Tabuchi, Ken, Morimoto, Akira
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Sprache:eng
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Zusammenfassung:Introduction Hematopoietic stem cell transplantation (HSCT) is one of the promising treatment strategies for children with refractory Langerhans cell histiocytosis (LCH), because of its immunomodulatory effects.Efficacy and indication of HSCT has been still undetermined. We analyzed the outcomes of HSCT in children with refractory LCH registered in the Transplant Registry Unified Management Program (TRUMP) conducted by the Japanese Society for Hematopoietic Cell Transplantation. Patients and methods Between 1996 and 2014, 30 patients
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2018-99-110711