CD4+ T cell subsets and Tax expression in HTLV-1 associated diseases
Human T lymphotropic virus type 1 (HTLV-1) infection displays variable clinical manifestations. These include inflammatory diseases such as HTLV-1 associated myelopathy (HAM) or immunosuppressive conditions such as Strongyloides stercoralis hyperinfection. The viral protein, Tax causes activation an...
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| Veröffentlicht in: | Pathogens and global health 2013-06, Vol.107 (4), p.202-206 |
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| creator | Barros, Nicolas Risco, Jorge Rodríguez, Carlos Sánchez, Cesar González, Elsa Tanaka, Yuetsu Gotuzzo, Eduardo Clinton White, A Montes, Martin |
| description | Human T lymphotropic virus type 1 (HTLV-1) infection displays variable clinical manifestations. These include inflammatory diseases such as HTLV-1 associated myelopathy (HAM) or immunosuppressive conditions such as Strongyloides stercoralis hyperinfection. The viral protein, Tax causes activation and proliferation of T cells. We hypothesize that the expression of Tax in T cell subsets characterizes the clinical manifestations of HTLV-1. To test this hypothesis, we measured T helper 1 effector cells and regulatory T cells (Tregs) among Tax expressing lymphocytes from peripheral blood mononuclear cells (PBMCs) of 32 HTLV-1 infected patients with HAM, with S. stercoralis co-infection or with asymptomatic infection. We observed increased ratios of Th1/Treg among Tax expressing lymphocytes in HAM patients. These data suggest that the expression of Tax among the different target cells may explain the variable presentation of HTLV-1. |
| doi_str_mv | 10.1179/2047773213Y.0000000091 |
| format | Article |
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These include inflammatory diseases such as HTLV-1 associated myelopathy (HAM) or immunosuppressive conditions such as Strongyloides stercoralis hyperinfection. The viral protein, Tax causes activation and proliferation of T cells. We hypothesize that the expression of Tax in T cell subsets characterizes the clinical manifestations of HTLV-1. To test this hypothesis, we measured T helper 1 effector cells and regulatory T cells (Tregs) among Tax expressing lymphocytes from peripheral blood mononuclear cells (PBMCs) of 32 HTLV-1 infected patients with HAM, with S. stercoralis co-infection or with asymptomatic infection. We observed increased ratios of Th1/Treg among Tax expressing lymphocytes in HAM patients. These data suggest that the expression of Tax among the different target cells may explain the variable presentation of HTLV-1.</description><identifier>ISSN: 2047-7724</identifier><identifier>EISSN: 2047-7732</identifier><identifier>DOI: 10.1179/2047773213Y.0000000091</identifier><identifier>PMID: 23816512</identifier><language>eng</language><publisher>London: Taylor & Francis</publisher><subject>Animals ; Biological and medical sciences ; CD4-Positive T-Lymphocytes - immunology ; Foxp3 ; Gene Expression ; Gene Products, tax - biosynthesis ; General aspects ; HTLV-1 ; Human T-lymphotropic virus 1 - immunology ; Humans ; Immunology ; Medical sciences ; Paraparesis, Tropical Spastic - complications ; Paraparesis, Tropical Spastic - immunology ; Regulatory T cells ; Short Communication ; Strongyloides stercoralis - isolation & purification ; Strongyloidiasis - immunology ; T-Lymphocyte Subsets - immunology ; T-Lymphocytes, Regulatory - immunology ; Tax ; Th1 ; Th1 Cells - immunology</subject><ispartof>Pathogens and global health, 2013-06, Vol.107 (4), p.202-206</ispartof><rights>W. 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Maney & Son Ltd 2013 2013</rights><rights>2014 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c502t-6f4d50066a8f952e6a15010107d82b1b1c219e95ff211e07a05ac5e3bb20544f3</citedby><cites>FETCH-LOGICAL-c502t-6f4d50066a8f952e6a15010107d82b1b1c219e95ff211e07a05ac5e3bb20544f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001472/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001472/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27487974$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23816512$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barros, Nicolas</creatorcontrib><creatorcontrib>Risco, Jorge</creatorcontrib><creatorcontrib>Rodríguez, Carlos</creatorcontrib><creatorcontrib>Sánchez, Cesar</creatorcontrib><creatorcontrib>González, Elsa</creatorcontrib><creatorcontrib>Tanaka, Yuetsu</creatorcontrib><creatorcontrib>Gotuzzo, Eduardo</creatorcontrib><creatorcontrib>Clinton White, A</creatorcontrib><creatorcontrib>Montes, Martin</creatorcontrib><title>CD4+ T cell subsets and Tax expression in HTLV-1 associated diseases</title><title>Pathogens and global health</title><addtitle>Pathog Glob Health</addtitle><description>Human T lymphotropic virus type 1 (HTLV-1) infection displays variable clinical manifestations. These include inflammatory diseases such as HTLV-1 associated myelopathy (HAM) or immunosuppressive conditions such as Strongyloides stercoralis hyperinfection. The viral protein, Tax causes activation and proliferation of T cells. We hypothesize that the expression of Tax in T cell subsets characterizes the clinical manifestations of HTLV-1. To test this hypothesis, we measured T helper 1 effector cells and regulatory T cells (Tregs) among Tax expressing lymphocytes from peripheral blood mononuclear cells (PBMCs) of 32 HTLV-1 infected patients with HAM, with S. stercoralis co-infection or with asymptomatic infection. We observed increased ratios of Th1/Treg among Tax expressing lymphocytes in HAM patients. These data suggest that the expression of Tax among the different target cells may explain the variable presentation of HTLV-1.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>Foxp3</subject><subject>Gene Expression</subject><subject>Gene Products, tax - biosynthesis</subject><subject>General aspects</subject><subject>HTLV-1</subject><subject>Human T-lymphotropic virus 1 - immunology</subject><subject>Humans</subject><subject>Immunology</subject><subject>Medical sciences</subject><subject>Paraparesis, Tropical Spastic - complications</subject><subject>Paraparesis, Tropical Spastic - immunology</subject><subject>Regulatory T cells</subject><subject>Short Communication</subject><subject>Strongyloides stercoralis - isolation & purification</subject><subject>Strongyloidiasis - immunology</subject><subject>T-Lymphocyte Subsets - immunology</subject><subject>T-Lymphocytes, Regulatory - immunology</subject><subject>Tax</subject><subject>Th1</subject><subject>Th1 Cells - immunology</subject><issn>2047-7724</issn><issn>2047-7732</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1r3DAQhkVpaUKSvxB0KRSKU40sWfalEDZpU1jIZVvoSYxluVXxWluNNx__vjK72aSnSgeNmOcdvZph7BzEBYBpPkqhjDGlhPLHhdivBl6x4zlRzJnXh1iqI3ZG9HtmKg1GyrfsSJY15Is8ZleLK_WBr7jzw8Bp25KfiOPY8RU-cP-wSZ4oxJGHkd-slt8L4EgUXcDJd7wL5JE8nbI3PQ7kz_bnCfv2-Xq1uCmWt1--Li6XhdNCTkXVq05nFxXWfaOlrxC0gLxNV8sWWnASGt_ovpcAXhgUGp32ZdtKoZXqyxP2aVd3s23XvnN-nBIOdpPCGtOjjRjsv5kx_LI_451VQoAyMhd4vy-Q4p-tp8muA81fx9HHLVnIfQEh6qbJaLVDXYpEyfeHZ0DYeQr2xRTs8xSy8PylyYPsqecZeLcHkBwOfcLRBXrmjKpNY1TmLndcGPuY1ngf09DZCR-HmJ5E5X_M_AUqhqFo</recordid><startdate>20130601</startdate><enddate>20130601</enddate><creator>Barros, Nicolas</creator><creator>Risco, Jorge</creator><creator>Rodríguez, Carlos</creator><creator>Sánchez, Cesar</creator><creator>González, Elsa</creator><creator>Tanaka, Yuetsu</creator><creator>Gotuzzo, Eduardo</creator><creator>Clinton White, A</creator><creator>Montes, Martin</creator><general>Taylor & Francis</general><general>Maney</general><general>Maney Publishing</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130601</creationdate><title>CD4+ T cell subsets and Tax expression in HTLV-1 associated diseases</title><author>Barros, Nicolas ; Risco, Jorge ; Rodríguez, Carlos ; Sánchez, Cesar ; González, Elsa ; Tanaka, Yuetsu ; Gotuzzo, Eduardo ; Clinton White, A ; Montes, Martin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c502t-6f4d50066a8f952e6a15010107d82b1b1c219e95ff211e07a05ac5e3bb20544f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>CD4-Positive T-Lymphocytes - immunology</topic><topic>Foxp3</topic><topic>Gene Expression</topic><topic>Gene Products, tax - biosynthesis</topic><topic>General aspects</topic><topic>HTLV-1</topic><topic>Human T-lymphotropic virus 1 - immunology</topic><topic>Humans</topic><topic>Immunology</topic><topic>Medical sciences</topic><topic>Paraparesis, Tropical Spastic - complications</topic><topic>Paraparesis, Tropical Spastic - immunology</topic><topic>Regulatory T cells</topic><topic>Short Communication</topic><topic>Strongyloides stercoralis - isolation & purification</topic><topic>Strongyloidiasis - immunology</topic><topic>T-Lymphocyte Subsets - immunology</topic><topic>T-Lymphocytes, Regulatory - immunology</topic><topic>Tax</topic><topic>Th1</topic><topic>Th1 Cells - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barros, Nicolas</creatorcontrib><creatorcontrib>Risco, Jorge</creatorcontrib><creatorcontrib>Rodríguez, Carlos</creatorcontrib><creatorcontrib>Sánchez, Cesar</creatorcontrib><creatorcontrib>González, Elsa</creatorcontrib><creatorcontrib>Tanaka, Yuetsu</creatorcontrib><creatorcontrib>Gotuzzo, Eduardo</creatorcontrib><creatorcontrib>Clinton White, A</creatorcontrib><creatorcontrib>Montes, Martin</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pathogens and global health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barros, Nicolas</au><au>Risco, Jorge</au><au>Rodríguez, Carlos</au><au>Sánchez, Cesar</au><au>González, Elsa</au><au>Tanaka, Yuetsu</au><au>Gotuzzo, Eduardo</au><au>Clinton White, A</au><au>Montes, Martin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CD4+ T cell subsets and Tax expression in HTLV-1 associated diseases</atitle><jtitle>Pathogens and global health</jtitle><addtitle>Pathog Glob Health</addtitle><date>2013-06-01</date><risdate>2013</risdate><volume>107</volume><issue>4</issue><spage>202</spage><epage>206</epage><pages>202-206</pages><issn>2047-7724</issn><eissn>2047-7732</eissn><abstract>Human T lymphotropic virus type 1 (HTLV-1) infection displays variable clinical manifestations. These include inflammatory diseases such as HTLV-1 associated myelopathy (HAM) or immunosuppressive conditions such as Strongyloides stercoralis hyperinfection. The viral protein, Tax causes activation and proliferation of T cells. We hypothesize that the expression of Tax in T cell subsets characterizes the clinical manifestations of HTLV-1. To test this hypothesis, we measured T helper 1 effector cells and regulatory T cells (Tregs) among Tax expressing lymphocytes from peripheral blood mononuclear cells (PBMCs) of 32 HTLV-1 infected patients with HAM, with S. stercoralis co-infection or with asymptomatic infection. We observed increased ratios of Th1/Treg among Tax expressing lymphocytes in HAM patients. 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| subjects | Animals Biological and medical sciences CD4-Positive T-Lymphocytes - immunology Foxp3 Gene Expression Gene Products, tax - biosynthesis General aspects HTLV-1 Human T-lymphotropic virus 1 - immunology Humans Immunology Medical sciences Paraparesis, Tropical Spastic - complications Paraparesis, Tropical Spastic - immunology Regulatory T cells Short Communication Strongyloides stercoralis - isolation & purification Strongyloidiasis - immunology T-Lymphocyte Subsets - immunology T-Lymphocytes, Regulatory - immunology Tax Th1 Th1 Cells - immunology |
| title | CD4+ T cell subsets and Tax expression in HTLV-1 associated diseases |
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