The effects of lycopene on intestinal injury due to methotrexate in rats
Objective: The aim of this study was to investigate the effects of lycopene (Lyc) on methotrexate (Mtx)-induced intestinal damage in rats. Method: Twenty-eight male Sprague Dawley rats were divided into four equal groups: control, Mtx, Lyc, and Mtx-L. Control group: Rats were given only the vehicle....
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| Veröffentlicht in: | Redox report : communications in free radical research 2016-05, Vol.21 (3), p.113-118 |
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| creator | Yucel, Yusuf Tabur, Suzan Gozeneli, Orhan Kocarslan, Sezen Seker, Ahmet Buyukaslan, Hasan Şavik, Emin Aktumen, Alpay Ozgonul, Abdullah Uzunkoy, Ali Aksoy, Nurten |
| description | Objective: The aim of this study was to investigate the effects of lycopene (Lyc) on methotrexate (Mtx)-induced intestinal damage in rats.
Method: Twenty-eight male Sprague Dawley rats were divided into four equal groups: control, Mtx, Lyc, and Mtx-L.
Control group: Rats were given only the vehicle.
Lyc group: Rats were given Lyc (10 mg/kg) with corn oil by oral gavage for 10 days.
Mtx group: Rats were injected intraperitoneally with a single dose of 20 mg/kg of Mtx and given corn oil by oral gavage.
Mtx-L group: Rats were treated with Lyc (10 mg/kg) for 10 days after a single dose of Mtx (20 mg/kg). All of the rats were euthanized using terminal anesthesia, and the intestinal tissues were removed for histological examination and for pro-inflammatory cytokine measurement (tumor necrosis factor alpha (TNF-α), interleukin-1 beta (IL-1β)), total oxidative status (TOS), total antioxidant capacity (TAC), and oxidative stress index (OSI).
Results: Mtx administration increased histopathological damage and increased TNF-α, IL-1β, TOS, TAC, and OSI levels in the small intestine tissues. Lyc therapy applied to the Mtx-L group provided significant improvement in all parameters of histopathological damage to the small intestine and significantly reduced the levels of IL-1β, TOS, and OSI in the intestinal tissues.
Conclusions: The results of this study indicate that Lyc might be useful for protecting intestinal damage induced by Mtx in rats by reducing the increased oxidative stress and pro-inflammatory cytokine (IL-1β) levels. |
| doi_str_mv | 10.1179/1351000215Y.0000000041 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1179_1351000215Y_0000000041</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1788227335</sourcerecordid><originalsourceid>FETCH-LOGICAL-c472t-b24b61cd95c55301d916d9260849bf657476f042932e3ed42923372868c14af83</originalsourceid><addsrcrecordid>eNqFkUtPGzEUha2qqFDoX0BedjOpHzN-bCoh1AISUjewYGU5nutm0Iyd2h4g_76OkgZY1Rsf6X733GsfhM4pWVAq9TfKO0oIYbR7WJD9aekHdEJlyxummfpYdYWaLXWMPuf8WBUXWn1Cx0zwTgslTtD13QoweA-uZBw9HjcuriEAjgEPoUAuQ7BjlY9z2uB-BlwinqCsYknwYgvUEk625DN05O2Y4cv-PkX3P3_cXV43t7-ubi4vbhvXSlaaJWuXgrped67rOKG9pqLXTBDV6qUXnWyl8KRlmjPg0FfBOJdMCeVoa73ip-j7znc9LyfoHYSS7GjWaZhs2phoB_O-EoaV-R2fjFBcCi6rwde9QYp_5vpAMw3ZwTjaAHHOhkqlGJOcdxUVO9SlmHMCfxhDidnGYN7EYF5jqI3nb5c8tP379wpc7IAh-Jgm-xzT2JtiN2NMPtnghmz4f4b8BZFJlq4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1788227335</pqid></control><display><type>article</type><title>The effects of lycopene on intestinal injury due to methotrexate in rats</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Yucel, Yusuf ; Tabur, Suzan ; Gozeneli, Orhan ; Kocarslan, Sezen ; Seker, Ahmet ; Buyukaslan, Hasan ; Şavik, Emin ; Aktumen, Alpay ; Ozgonul, Abdullah ; Uzunkoy, Ali ; Aksoy, Nurten</creator><creatorcontrib>Yucel, Yusuf ; Tabur, Suzan ; Gozeneli, Orhan ; Kocarslan, Sezen ; Seker, Ahmet ; Buyukaslan, Hasan ; Şavik, Emin ; Aktumen, Alpay ; Ozgonul, Abdullah ; Uzunkoy, Ali ; Aksoy, Nurten</creatorcontrib><description>Objective: The aim of this study was to investigate the effects of lycopene (Lyc) on methotrexate (Mtx)-induced intestinal damage in rats.
Method: Twenty-eight male Sprague Dawley rats were divided into four equal groups: control, Mtx, Lyc, and Mtx-L.
Control group: Rats were given only the vehicle.
Lyc group: Rats were given Lyc (10 mg/kg) with corn oil by oral gavage for 10 days.
Mtx group: Rats were injected intraperitoneally with a single dose of 20 mg/kg of Mtx and given corn oil by oral gavage.
Mtx-L group: Rats were treated with Lyc (10 mg/kg) for 10 days after a single dose of Mtx (20 mg/kg). All of the rats were euthanized using terminal anesthesia, and the intestinal tissues were removed for histological examination and for pro-inflammatory cytokine measurement (tumor necrosis factor alpha (TNF-α), interleukin-1 beta (IL-1β)), total oxidative status (TOS), total antioxidant capacity (TAC), and oxidative stress index (OSI).
Results: Mtx administration increased histopathological damage and increased TNF-α, IL-1β, TOS, TAC, and OSI levels in the small intestine tissues. Lyc therapy applied to the Mtx-L group provided significant improvement in all parameters of histopathological damage to the small intestine and significantly reduced the levels of IL-1β, TOS, and OSI in the intestinal tissues.
Conclusions: The results of this study indicate that Lyc might be useful for protecting intestinal damage induced by Mtx in rats by reducing the increased oxidative stress and pro-inflammatory cytokine (IL-1β) levels.</description><identifier>ISSN: 1351-0002</identifier><identifier>EISSN: 1743-2928</identifier><identifier>DOI: 10.1179/1351000215Y.0000000041</identifier><identifier>PMID: 26359686</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Animals ; Antioxidants - metabolism ; Carotenoids - therapeutic use ; Glutathione - metabolism ; IL-1β ; Interleukin-1beta - metabolism ; Intestinal injury ; Intestinal Mucosa - metabolism ; Intestines - drug effects ; Intestines - injuries ; Lycopene ; Male ; Malondialdehyde ; Methotrexate ; Methotrexate - toxicity ; Oxidative stress ; Oxidative Stress - drug effects ; Rats ; Rats, Sprague-Dawley ; TNF-α ; Tumor Necrosis Factor-alpha - metabolism</subject><ispartof>Redox report : communications in free radical research, 2016-05, Vol.21 (3), p.113-118</ispartof><rights>2016 Informa UK Limited, trading as Taylor & Francis Group 2016</rights><rights>2016 Informa UK Limited, trading as Taylor & Francis Group 2016 Informa UK Limited, trading as Taylor & Francis Group</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-b24b61cd95c55301d916d9260849bf657476f042932e3ed42923372868c14af83</citedby><cites>FETCH-LOGICAL-c472t-b24b61cd95c55301d916d9260849bf657476f042932e3ed42923372868c14af83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6837637/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6837637/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26359686$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yucel, Yusuf</creatorcontrib><creatorcontrib>Tabur, Suzan</creatorcontrib><creatorcontrib>Gozeneli, Orhan</creatorcontrib><creatorcontrib>Kocarslan, Sezen</creatorcontrib><creatorcontrib>Seker, Ahmet</creatorcontrib><creatorcontrib>Buyukaslan, Hasan</creatorcontrib><creatorcontrib>Şavik, Emin</creatorcontrib><creatorcontrib>Aktumen, Alpay</creatorcontrib><creatorcontrib>Ozgonul, Abdullah</creatorcontrib><creatorcontrib>Uzunkoy, Ali</creatorcontrib><creatorcontrib>Aksoy, Nurten</creatorcontrib><title>The effects of lycopene on intestinal injury due to methotrexate in rats</title><title>Redox report : communications in free radical research</title><addtitle>Redox Rep</addtitle><description>Objective: The aim of this study was to investigate the effects of lycopene (Lyc) on methotrexate (Mtx)-induced intestinal damage in rats.
Method: Twenty-eight male Sprague Dawley rats were divided into four equal groups: control, Mtx, Lyc, and Mtx-L.
Control group: Rats were given only the vehicle.
Lyc group: Rats were given Lyc (10 mg/kg) with corn oil by oral gavage for 10 days.
Mtx group: Rats were injected intraperitoneally with a single dose of 20 mg/kg of Mtx and given corn oil by oral gavage.
Mtx-L group: Rats were treated with Lyc (10 mg/kg) for 10 days after a single dose of Mtx (20 mg/kg). All of the rats were euthanized using terminal anesthesia, and the intestinal tissues were removed for histological examination and for pro-inflammatory cytokine measurement (tumor necrosis factor alpha (TNF-α), interleukin-1 beta (IL-1β)), total oxidative status (TOS), total antioxidant capacity (TAC), and oxidative stress index (OSI).
Results: Mtx administration increased histopathological damage and increased TNF-α, IL-1β, TOS, TAC, and OSI levels in the small intestine tissues. Lyc therapy applied to the Mtx-L group provided significant improvement in all parameters of histopathological damage to the small intestine and significantly reduced the levels of IL-1β, TOS, and OSI in the intestinal tissues.
Conclusions: The results of this study indicate that Lyc might be useful for protecting intestinal damage induced by Mtx in rats by reducing the increased oxidative stress and pro-inflammatory cytokine (IL-1β) levels.</description><subject>Animals</subject><subject>Antioxidants - metabolism</subject><subject>Carotenoids - therapeutic use</subject><subject>Glutathione - metabolism</subject><subject>IL-1β</subject><subject>Interleukin-1beta - metabolism</subject><subject>Intestinal injury</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Intestines - drug effects</subject><subject>Intestines - injuries</subject><subject>Lycopene</subject><subject>Male</subject><subject>Malondialdehyde</subject><subject>Methotrexate</subject><subject>Methotrexate - toxicity</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>TNF-α</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><issn>1351-0002</issn><issn>1743-2928</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtPGzEUha2qqFDoX0BedjOpHzN-bCoh1AISUjewYGU5nutm0Iyd2h4g_76OkgZY1Rsf6X733GsfhM4pWVAq9TfKO0oIYbR7WJD9aekHdEJlyxummfpYdYWaLXWMPuf8WBUXWn1Cx0zwTgslTtD13QoweA-uZBw9HjcuriEAjgEPoUAuQ7BjlY9z2uB-BlwinqCsYknwYgvUEk625DN05O2Y4cv-PkX3P3_cXV43t7-ubi4vbhvXSlaaJWuXgrped67rOKG9pqLXTBDV6qUXnWyl8KRlmjPg0FfBOJdMCeVoa73ip-j7znc9LyfoHYSS7GjWaZhs2phoB_O-EoaV-R2fjFBcCi6rwde9QYp_5vpAMw3ZwTjaAHHOhkqlGJOcdxUVO9SlmHMCfxhDidnGYN7EYF5jqI3nb5c8tP379wpc7IAh-Jgm-xzT2JtiN2NMPtnghmz4f4b8BZFJlq4</recordid><startdate>20160503</startdate><enddate>20160503</enddate><creator>Yucel, Yusuf</creator><creator>Tabur, Suzan</creator><creator>Gozeneli, Orhan</creator><creator>Kocarslan, Sezen</creator><creator>Seker, Ahmet</creator><creator>Buyukaslan, Hasan</creator><creator>Şavik, Emin</creator><creator>Aktumen, Alpay</creator><creator>Ozgonul, Abdullah</creator><creator>Uzunkoy, Ali</creator><creator>Aksoy, Nurten</creator><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160503</creationdate><title>The effects of lycopene on intestinal injury due to methotrexate in rats</title><author>Yucel, Yusuf ; Tabur, Suzan ; Gozeneli, Orhan ; Kocarslan, Sezen ; Seker, Ahmet ; Buyukaslan, Hasan ; Şavik, Emin ; Aktumen, Alpay ; Ozgonul, Abdullah ; Uzunkoy, Ali ; Aksoy, Nurten</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-b24b61cd95c55301d916d9260849bf657476f042932e3ed42923372868c14af83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Antioxidants - metabolism</topic><topic>Carotenoids - therapeutic use</topic><topic>Glutathione - metabolism</topic><topic>IL-1β</topic><topic>Interleukin-1beta - metabolism</topic><topic>Intestinal injury</topic><topic>Intestinal Mucosa - metabolism</topic><topic>Intestines - drug effects</topic><topic>Intestines - injuries</topic><topic>Lycopene</topic><topic>Male</topic><topic>Malondialdehyde</topic><topic>Methotrexate</topic><topic>Methotrexate - toxicity</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>TNF-α</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yucel, Yusuf</creatorcontrib><creatorcontrib>Tabur, Suzan</creatorcontrib><creatorcontrib>Gozeneli, Orhan</creatorcontrib><creatorcontrib>Kocarslan, Sezen</creatorcontrib><creatorcontrib>Seker, Ahmet</creatorcontrib><creatorcontrib>Buyukaslan, Hasan</creatorcontrib><creatorcontrib>Şavik, Emin</creatorcontrib><creatorcontrib>Aktumen, Alpay</creatorcontrib><creatorcontrib>Ozgonul, Abdullah</creatorcontrib><creatorcontrib>Uzunkoy, Ali</creatorcontrib><creatorcontrib>Aksoy, Nurten</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Redox report : communications in free radical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yucel, Yusuf</au><au>Tabur, Suzan</au><au>Gozeneli, Orhan</au><au>Kocarslan, Sezen</au><au>Seker, Ahmet</au><au>Buyukaslan, Hasan</au><au>Şavik, Emin</au><au>Aktumen, Alpay</au><au>Ozgonul, Abdullah</au><au>Uzunkoy, Ali</au><au>Aksoy, Nurten</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of lycopene on intestinal injury due to methotrexate in rats</atitle><jtitle>Redox report : communications in free radical research</jtitle><addtitle>Redox Rep</addtitle><date>2016-05-03</date><risdate>2016</risdate><volume>21</volume><issue>3</issue><spage>113</spage><epage>118</epage><pages>113-118</pages><issn>1351-0002</issn><eissn>1743-2928</eissn><abstract>Objective: The aim of this study was to investigate the effects of lycopene (Lyc) on methotrexate (Mtx)-induced intestinal damage in rats.
Method: Twenty-eight male Sprague Dawley rats were divided into four equal groups: control, Mtx, Lyc, and Mtx-L.
Control group: Rats were given only the vehicle.
Lyc group: Rats were given Lyc (10 mg/kg) with corn oil by oral gavage for 10 days.
Mtx group: Rats were injected intraperitoneally with a single dose of 20 mg/kg of Mtx and given corn oil by oral gavage.
Mtx-L group: Rats were treated with Lyc (10 mg/kg) for 10 days after a single dose of Mtx (20 mg/kg). All of the rats were euthanized using terminal anesthesia, and the intestinal tissues were removed for histological examination and for pro-inflammatory cytokine measurement (tumor necrosis factor alpha (TNF-α), interleukin-1 beta (IL-1β)), total oxidative status (TOS), total antioxidant capacity (TAC), and oxidative stress index (OSI).
Results: Mtx administration increased histopathological damage and increased TNF-α, IL-1β, TOS, TAC, and OSI levels in the small intestine tissues. Lyc therapy applied to the Mtx-L group provided significant improvement in all parameters of histopathological damage to the small intestine and significantly reduced the levels of IL-1β, TOS, and OSI in the intestinal tissues.
Conclusions: The results of this study indicate that Lyc might be useful for protecting intestinal damage induced by Mtx in rats by reducing the increased oxidative stress and pro-inflammatory cytokine (IL-1β) levels.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>26359686</pmid><doi>10.1179/1351000215Y.0000000041</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Antioxidants - metabolism Carotenoids - therapeutic use Glutathione - metabolism IL-1β Interleukin-1beta - metabolism Intestinal injury Intestinal Mucosa - metabolism Intestines - drug effects Intestines - injuries Lycopene Male Malondialdehyde Methotrexate Methotrexate - toxicity Oxidative stress Oxidative Stress - drug effects Rats Rats, Sprague-Dawley TNF-α Tumor Necrosis Factor-alpha - metabolism |
| title | The effects of lycopene on intestinal injury due to methotrexate in rats |
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