1 H-magnetic resonance spectroscopy and its role in predicting neurodevelopmental impairment in preterm neonates: A systematic review

1 H-magnetic resonance spectroscopy and its role in predicting neurodevelopmental impairment in preterm neonates: A systematic review

To assess the diagnostic utility of proton ( H) magnetic resonance spectroscopy in early diagnosis of neurodevelopmental impairment in preterm newborns. Systematic review performed in compliance with the PRISMA statements. Eligible articles were searched in MEDLINE, Scopus, and ISI Web of Science da...

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Veröffentlicht in:The neuroradiology journal 2022-12, Vol.35 (6), p.19714009221102454-677
Hauptverfasser: Laccetta, Gianluigi, De Nardo, Maria Chiara, Cellitti, Raffaella, Angeloni, Ugo, Terrin, Gianluca
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container_end_page 677
container_issue 6
container_start_page 19714009221102454
container_title The neuroradiology journal
container_volume 35
creator Laccetta, Gianluigi
De Nardo, Maria Chiara
Cellitti, Raffaella
Angeloni, Ugo
Terrin, Gianluca
description To assess the diagnostic utility of proton ( H) magnetic resonance spectroscopy in early diagnosis of neurodevelopmental impairment in preterm newborns. Systematic review performed in compliance with the PRISMA statements. Eligible articles were searched in MEDLINE, Scopus, and ISI Web of Science databases using the following medical subject headings and terms: "magnetic resonance spectroscopy," "infant," and "newborn." Studies of any design published until 20 December 2021 and fulfilling the following criteria were selected: (1) studies including newborns with gestational age at birth
doi_str_mv 10.1177/19714009221102454
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N-acetylaspartate (NAA)/choline (Cho) was the most studied metabolite ratio. Lower NAA/Cho ratio in basal ganglia and thalamus was associated with adverse motor, cognitive, and language outcomes, and worse global neurodevelopment. Lower NAA/Cho ratio in white matter was associated with cognitive impairment. However, some associations came from single studies or were discordant among studies. The quality of included studies was low. H-MRS could be a promising tool for early diagnosis of neurodevelopmental impairment. 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source SAGE Complete A-Z List; PubMed Central
title 1 H-magnetic resonance spectroscopy and its role in predicting neurodevelopmental impairment in preterm neonates: A systematic review
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